preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
fulltophigh inflation risk
Bacteroides ovatus
obesity
Bacteroides ovatus has meaningful literature visibility in obesity, but the current evidence mix suggests a substantial risk of overclaiming.
Bacteroides ovatus shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.
bacteroides_ovatus
Credibility score
60
Human translation
2/5
Reproducibility
4/5
Novelty
2/5
Actionability
3/5
Credibility 60Human translation 2/5Reproducibility 4/5Novelty 2/5Actionability 3/5
Why this scores the way it does
- strong central evidence base
- dense review literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
16 papersCitrus polymethoxyflavones attenuate metabolic syndrome by regulating gut microbiome and amino acid metabolism.
2020Science advances
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alteration of the Gut Microbiome in Normal and Overweight School Children from Selangor with Lactobacillus Fermented Milk Administration.
2020Evolutionary bioinformatics online
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota alterations reveal potential gut-brain axis changes in polycystic ovary syndrome.
2021Journal of endocrinological investigation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota signatures of insulin resistance, inflammation, and metabolic syndrome in youth with obesity: a pilot study.
2021Acta diabetologica
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A metabolomics pipeline for the mechanistic interrogation of the gut microbiome.
2021Nature
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans.
2022Cell
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enterotypes in asthenospermia patients with obesity.
2022Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of Fecal Microbiota Transplantation on Gut Bacterial Bile Acid Metabolism in Humans.
2022Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer.
2023Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Liver Bacterial Colonization in Patients with Obesity and Gut Dysbiosis.
2024Obesity surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of differences in intestinal flora associated with different BMI status in colorectal cancer patients.
2024Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss Bifidobacterium breve BBr60 Intervention: A Randomized Controlled Trial.
2024International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study.
2024Genome medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mucosal Hub Bacteria as Potential Targets for Improving High-Fat Diet-Related Intestinal Barrier Injury.
2024The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota-derived 4-hydroxyphenylacetic acid from resveratrol supplementation prevents obesity through SIRT1 signaling activation.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Unraveling the Anti-Obesity Potential of White Kidney Bean α-Amylase Inhibitors: Mechanistic Insights From Enzyme Kinetics to Gut Microbiota Modulation.
2025Food science & nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
19 papersGanoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.
2015Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.
2016Cell
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention.
2017Nature medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.
2018Nature medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Substrate Use Prioritization by a Coculture of Five Species of Gut Bacteria Fed Mixtures of Arabinoxylan, Xyloglucan, β-Glucan, and Pectin.
2020Applied and environmental microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism.
2020The British journal of nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Undaria pinnatifida improves obesity-related outcomes in association with gut microbiota and metabolomics modulation in high-fat diet-fed mice.
2020Applied microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis.
2021Cell metabolism
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides ovatus-mediated CD27- MAIT cell activation is associated with obesity-related T2D progression.
2022Cellular & molecular immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The interplay between PCOS pathology and diet on gut microbiota in a mouse model.
2022Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism.
2022Nature metabolism
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Anti-obesity activity of human gut microbiota Bacteroides stercoris KGMB02265.
2023Archives of microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Semaglutide alleviates gut microbiota dysbiosis induced by a high-fat diet.
2024European journal of pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice.
2024Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparative analysis of gut microbiota in children with obstructive sleep apnea: assessing the efficacy of 16S rRNA gene sequencing in metabolic function prediction based on weight status.
2024Frontiers in endocrinology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice but not in chow-fed mice.
2024Proceedings of the National Academy of Sciences of the United States of America
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Obesity as Inducer of Cognitive Function Decline via Dysbiosis of Gut Microbiota in Rats.
2024Brain sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic-Comorbidities Related Signatures in Craniopharyngioma.
2024Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The role of gut microbiota in Tirzepatide-mediated alleviation of high-fat diet-induced obesity.
2025European journal of pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
17 papersHost-bacterial mutualism in the human intestine.
2005Science (New York, N.Y.)
Relevant review or meta-analysis for the signal-disease area.
Influence of gut microbiota on the development and progression of nonalcoholic steatohepatitis.
2018European journal of nutrition
Relevant review or meta-analysis for the signal-disease area.
Diet and microbiota linked in health and disease.
2018Food & function
Relevant review or meta-analysis for the signal-disease area.
Childhood Obesity and Firmicutes/Bacteroidetes Ratio in the Gut Microbiota: A Systematic Review.
2018Childhood obesity (Print)
Relevant review or meta-analysis for the signal-disease area.
Microbial enterotypes in personalized nutrition and obesity management.
2018The American journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Human microbiome and metabolic health: An overview of systematic reviews.
2022Obesity reviews : an official journal of the International Association for the Study of Obesity
Relevant review or meta-analysis for the signal-disease area.
The Role of Gut Microbiota-Brain Axis in Pathophysiology of ADHD: A Systematic Review.
2022Journal of attention disorders
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota and physical exercise in obesity and diabetes - A systematic review.
2022Nutrition, metabolism, and cardiovascular diseases : NMCD
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota: Therapeutic Targets of Ginseng Against Multiple Disorders and Ginsenoside Transformation.
2022Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
The Role of Next-Generation Probiotics in Obesity and Obesity-Associated Disorders: Current Knowledge and Future Perspectives.
2023International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer.
2023Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Relevant review or meta-analysis for the signal-disease area.
Can prebiotics help tackle the childhood obesity epidemic?
2023Frontiers in endocrinology
Relevant review or meta-analysis for the signal-disease area.
The Effects of the Mediterranean Diet on Health and Gut Microbiota.
2023Nutrients
Relevant review or meta-analysis for the signal-disease area.
Meta-analysis reveals obesity associated gut microbial alteration patterns and reproducible contributors of functional shift.
2024Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Impact of vaginal seeding on the gut microbiome of infants born via cesarean section: A systematic review.
2024The Journal of infection
Relevant review or meta-analysis for the signal-disease area.
Effects of GLP-1 Analogues and Agonists on the Gut Microbiota: A Systematic Review.
2025Nutrients
Relevant review or meta-analysis for the signal-disease area.
The gut microbiota-bile acid axis: a crucial regulator of immune function and metabolic health.
2025World journal of microbiology & biotechnology
Relevant review or meta-analysis for the signal-disease area.