preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
fulltophigh inflation risk
Bacteroides ovatus
crohn's disease
Bacteroides ovatus has meaningful literature visibility in crohn's disease, but the current evidence mix suggests a substantial risk of overclaiming.
Bacteroides ovatus shows a strong literature footprint in crohn's disease, with substantial central evidence and broader supporting literature.
bacteroides_ovatus
Credibility score
51
Human translation
2/5
Reproducibility
4/5
Novelty
3/5
Actionability
4/5
Credibility 51Human translation 2/5Reproducibility 4/5Novelty 3/5Actionability 4/5
Why this scores the way it does
- strong central evidence base
- meaningful supporting human literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
- retrieval noise or disease-specificity issues may remain
Internal review flags
1 flagsPrimary central evidence
15 papersBacteroides ovatus as the predominant commensal intestinal microbe causing a systemic antibody response in inflammatory bowel disease.
2002Clinical and diagnostic laboratory immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of a metal-independent CAZy family 6 glycosyltransferase from Bacteroides ovatus.
2009The Journal of biological chemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Temporal bacterial community dynamics vary among ulcerative colitis patients after fecal microbiota transplantation.
2013The American journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Quantitative microbiome profiling links gut community variation to microbial load.
2017Nature
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.
2019Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis.
2019Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Inter-kingdom relationships in Crohn's disease explored using a multi-omics approach.
2021Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enterotoxigenic Bacteroidesfragilis Promotes Intestinal Inflammation and Malignancy by Inhibiting Exosome-Packaged miR-149-3p.
2021Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Immunoglobulin subtype-coated bacteria are correlated with the disease activity of inflammatory bowel disease.
2021Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity.
2022Nature microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Location-specific signatures of Crohn's disease at a multi-omics scale.
2022Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease.
2024Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease.
2024Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Estrogen-related receptor alpha mitigates radiation-induced bowel injury through gut enrichment of Bacteroides vulgatus.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Decoding IBD progression: a dynamic biomarker atlas for personalized disease stratification.
2025Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
2 papersAdalimumab Therapy Improves Intestinal Dysbiosis in Crohn's Disease.
2019Journal of clinical medicine
Human primary paper with plausible association relevance to the disease context.
Genomes of Bacteroides ovatus, B. cellulosilyticus, B. uniformis, Phocaeicola vulgatus, and P. dorei isolated from gut cavernous fistulous tract micropathologies in Crohn's disease.
2024Microbiology resource announcements
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
21 papersTreatment of colitis with a commensal gut bacterium engineered to secrete human TGF-β1 under the control of dietary xylan 1.
2011Inflammatory bowel diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Novel xylan-controlled delivery of therapeutic proteins to inflamed colon by the human anaerobic commensal bacterium.
2013Annals of the Royal College of Surgeons of England
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diet rapidly and reproducibly alters the human gut microbiome.
2014Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.
2017Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides ovatus ATCC 8483 monotherapy is superior to traditional fecal transplant and multi-strain bacteriotherapy in a murine colitis model.
2019Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Crohn's disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response.
2019eLife
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation.
2020Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats.
2021Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Discovery of bioactive microbial gene products in inflammatory bowel disease.
2022Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Amelioration of Colitis by a Gut Bacterial Consortium Producing Anti-Inflammatory Secondary Bile Acids.
2023Microbiology spectrum
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis attenuate clinical symptoms of experimental colitis by regulating Treg/Th17 cell balance and intestinal barrier integrity.
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Porphyromonas gingivalis aggravates colitis via a gut microbiota-linoleic acid metabolism-Th17/Treg cell balance axis.
2024Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides uniformis degrades β-glucan to promote Lactobacillus johnsonii improving indole-3-lactic acid levels in alleviating colitis.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Vinegar-processed Schisandra Chinensis enhanced therapeutic effects on colitis-induced depression through tryptophan metabolism.
2024Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A highly conserved SusCD transporter determines the import and species-specific antagonism of Bacteroides ubiquitin homologues.
2024Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis.
2024Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides uniformis ameliorates pro-inflammatory diet-exacerbated colitis by targeting endoplasmic reticulum stress-mediated ferroptosis.
2025Journal of advanced research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Carbohydrate Deacetylase Unique to Gut Microbe Bacteroides Reveals Atypical Structure.
2025Biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The inflammatory bowel disease and gut microbiome are restored by employing metformin-loaded alginate-shelled microcapsules.
2025Journal of controlled release : official journal of the Controlled Release Society
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The gut microbiome and metabolomic alterations underlying colitis-induced encephalopathy in mice: mechanistic insight.
2025Behavioral and brain functions : BBF
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Multiomics Analysis of Bacteroides cellulosilyticus Anticolitis via Gut Microbiota Metabolite-Mediated PI3K-Akt Signaling Pathway.
2025Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
6 papersRole of antibiotics for treatment of inflammatory bowel disease.
2016World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Smoking and the intestinal microbiome.
2018Archives of microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Is a Potential Biomarker in Inflammatory Bowel Disease.
2021Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.
Intestinal phages interact with bacteria and are involved in human diseases.
2022Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota, inflammatory bowel disease and colorectal cancer.
2022World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Pathobionts in Inflammatory Bowel Disease: Origins, Underlying Mechanisms, and Implications for Clinical Care.
2024Gastroenterology
Relevant review or meta-analysis for the signal-disease area.