review_heavy
Review literature is very dense relative to primary central evidence.
fulltoplow inflation risk
Bacteroides ovatus
colorectal cancer
Bacteroides ovatus looks like a credible signal in colorectal cancer, though some caution is still warranted.
Bacteroides ovatus shows a strong literature footprint in colorectal cancer, with substantial central evidence and broader supporting literature.
bacteroides_ovatus
Credibility score
67
Human translation
3/5
Reproducibility
5/5
Novelty
1/5
Actionability
3/5
Credibility 67Human translation 3/5Reproducibility 5/5Novelty 1/5Actionability 3/5
Why this scores the way it does
- strong central evidence base
- dense review literature
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
17 papersAnalysis of Fusobacterium persistence and antibiotic response in colorectal cancer.
2017Science (New York, N.Y.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.
2018Science (New York, N.Y.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment.
2019Cell death & disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A novel faecal Lachnoclostridium marker for the non-invasive diagnosis of colorectal adenoma and cancer.
2020Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterizing the composition of intestinal microflora by 16S rRNA gene sequencing.
2020World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacterial Alterations in Post-Cholecystectomy Patients Are Associated With Colorectal Cancer.
2020Frontiers in oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enterotoxigenic Bacteroidesfragilis Promotes Intestinal Inflammation and Malignancy by Inhibiting Exosome-Packaged miR-149-3p.
2021Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer.
2023Cancer cell
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer.
2023Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identifying and ranking causal microbial biomarkers for colorectal cancer at different cancer subsites and stages: a Mendelian randomization study.
2023Frontiers in oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Salivary and fecal microbiota: potential new biomarkers for early screening of colorectal polyps.
2023Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of differences in intestinal flora associated with different BMI status in colorectal cancer patients.
2024Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome model predicts response to neoadjuvant immunotherapy plus chemoradiotherapy in rectal cancer.
2024Med (New York, N.Y.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
An Empirical Dietary Pattern Associated With the Gut Microbial Features in Relation to Colorectal Cancer Risk.
2024Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of Gut Microbiome in Patients with Colorectal Advanced Adenoma by Metagenomic Analyses.
2024The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Cell free supernatants of Bifidobacterium adolescentis and Bifidobacterium longum suppress the tumor growth in colorectal cancer organoid model.
2025Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
KAJF alleviated colorectal cancer liver metastasis by reshaping the gut microbiota and inhibiting M2-like macrophage polarization.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
11 papersDynamic microbe and molecule networks in a mouse model of colitis-associated colorectal cancer.
2014Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Carcinogenesis and Gut Microbiota].
2019Gan to kagaku ryoho. Cancer & chemotherapy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation.
2020Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Micro-coevolution of host genetics with gut microbiome in three Chinese ethnic groups.
2021Journal of genetics and genomics = Yi chuan xue bao
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteremia With Anaerobic Bacteria and Association With Colorectal Cancer: A Population-based Cohort Study.
2022Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Association between gut microbiota and CpG island methylator phenotype in colorectal cancer.
2024Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway.
2024iMeta
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Disruption of the intestinal clock drives dysbiosis and impaired barrier function in colorectal cancer.
2024Science advances
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity.
2025Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression.
2025Cell metabolism
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis.
2025Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
24 papersGut microbiota imbalance and colorectal cancer.
2016World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota, Inflammation, and Colorectal Cancer.
2016Annual review of microbiology
Relevant review or meta-analysis for the signal-disease area.
Food, microbiome and colorectal cancer.
2018Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota in colorectal cancer: mechanisms of action and clinical applications.
2019Nature reviews. Gastroenterology & hepatology
Relevant review or meta-analysis for the signal-disease area.
The Four Horsemen in Colon Cancer.
2019Journal of oncology
Relevant review or meta-analysis for the signal-disease area.
Gallstone Disease and Microbiome.
2020Microorganisms
Relevant review or meta-analysis for the signal-disease area.
The Intestinal Microbiota and Colorectal Cancer.
2020Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota-derived metabolites in CRC progression and causation.
2021Journal of cancer research and clinical oncology
Relevant review or meta-analysis for the signal-disease area.
Tumorigenic bacteria in colorectal cancer: mechanisms and treatments.
2021Cancer biology & medicine
Relevant review or meta-analysis for the signal-disease area.
Microbe-based management for colorectal cancer.
2021Chinese medical journal
Relevant review or meta-analysis for the signal-disease area.
Carcinogenic microbiota and its role in colorectal cancer development.
2022Seminars in cancer biology
Relevant review or meta-analysis for the signal-disease area.
Colorectal cancer: the facts in the case of the microbiota.
2022The Journal of clinical investigation
Relevant review or meta-analysis for the signal-disease area.
Microbiome and colorectal carcinogenesis: Linked mechanisms and racial differences.
2022World journal of gastrointestinal oncology
Relevant review or meta-analysis for the signal-disease area.
Meta-Analysis of Altered Gut Microbiota Reveals Microbial and Metabolic Biomarkers for Colorectal Cancer.
2022Microbiology spectrum
Relevant review or meta-analysis for the signal-disease area.
Intestinal phages interact with bacteria and are involved in human diseases.
2022Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota, inflammatory bowel disease and colorectal cancer.
2022World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota in Colorectal Cancer: Biological Role and Therapeutic Opportunities.
2023Cancers
Relevant review or meta-analysis for the signal-disease area.
Intestinal bacteria and colorectal cancer: etiology and treatment.
2023Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer.
2023Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Relevant review or meta-analysis for the signal-disease area.
Colorectal cancer and gut microbiota studies in China.
2023Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota and Colorectal Cancer: A Balance Between Risk and Protection.
2025International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Intestinal dysbiosis and colorectal cancer.
2025Chinese medical journal
Relevant review or meta-analysis for the signal-disease area.
Emerging New Treatments for Colon Cancer.
2025Current medicinal chemistry
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota and diet in colorectal cancer: Converging determinants of carcinogenesis.
2026Gut microbes
Relevant review or meta-analysis for the signal-disease area.