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Bacteroides fragilis

ulcerative colitis

Bacteroides fragilis looks like a credible signal in ulcerative colitis, though some caution is still warranted.

Bacteroides fragilis shows a strong literature footprint in ulcerative colitis, with substantial central evidence and broader supporting literature.

bacteroides_fragilis
Credibility score
100
Human translation
3/5
Reproducibility
5/5
Novelty
1/5
Actionability
5/5
Credibility 100Human translation 3/5Reproducibility 5/5Novelty 1/5Actionability 5/5
Why this scores the way it does
  • strong central evidence base
  • substantial preclinical support
Main caveats
  • directionality and confounding still require curated review

Primary central evidence

35 papers
Characterization of antibody responses against rectal mucosa-associated bacterial flora in patients with ulcerative colitis.
2000
Journal of gastroenterology and hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease.
2005
Journal of clinical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Prevalence of Bacteroides and Prevotella spp. in ulcerative colitis.
2006
Journal of medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease.
2008
International journal of medical microbiology : IJMM
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota.
2010
BMC gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations in the mucosa-associated bacterial composition in Crohn's disease: a pilot study.
2016
International journal of colorectal disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Increased Enterococcus faecalis infection is associated with clinically active Crohn disease.
2016
Medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.
2019
Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment.
2019
Cell death & disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Correlation of diet, microbiota and metabolite networks in inflammatory bowel disease.
2019
Journal of digestive diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A randomized controlled trial investigating the effect of a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols on the intestinal microbiome and inflammation in patients with ulcerative colitis: study protocol for a randomized controlled trial.
2020
Trials
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of soy milk consumption on gut microbiota, inflammatory markers, and disease severity in patients with ulcerative colitis: a study protocol for a randomized clinical trial.
2020
Trials
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Capsular Polysaccharide From Bacteroides fragilis Protects Against Ulcerative Colitis in an Undegraded Form.
2020
Frontiers in pharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Stool preparation under anaerobic conditions contributes to retention of obligate anaerobes: potential improvement for fecal microbiota transplantation.
2021
BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intestinal flora alterations in patients with ulcerative colitis and their association with inflammation.
2021
Experimental and therapeutic medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Long-Term Efficacy of Low-Intensity Single Donor Fecal Microbiota Transplantation in Ulcerative Colitis and Outcome-Specific Gut Bacteria.
2021
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity.
2022
Nature microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identification of gut microbiome and transcriptome changes in ulcerative colitis and pouchitis.
2022
Scandinavian journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of gut Microbiome alteration in Ulcerative Colitis patients on disease severity and outcome.
2023
Clinical and experimental medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacterial Oncotraits Rather than Spatial Organization Are Associated with Dysplasia in Ulcerative Colitis.
2023
Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamics of the Gut Mycobiome in Patients With Ulcerative Colitis.
2024
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The impact of gut microbiome enterotypes on ulcerative colitis: identifying key bacterial species and revealing species co-occurrence networks using machine learning.
2024
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbially catalyzed conjugation of GABA and tyramine to bile acids.
2024
Journal of bacteriology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Berberine regulates intestinal microbiome and metabolism homeostasis to treat ulcerative colitis.
2024
Life sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of microbial communities and the profile of sulfate-reducing bacteria in patients with ulcerative colitis and their association with bowel diseases: a pilot study.
2024
Microbial cell (Graz, Austria)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrated Analysis of Microbiome and Metabolome Reveals Disease-Specific Profiles in Inflammatory Bowel Diseases and Intestinal Behçet's Disease.
2024
International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Core microbiome-associated proteins associated with ulcerative colitis interact with cytokines for synergistic or antagonistic effects on gut bacteria.
2024
The ISME journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Sustained mucosal colonization and fecal metabolic dysfunction by Bacteroides associates with fecal microbial transplant failure in ulcerative colitis patients.
2024
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of the Gut Microbiome and TMAO Levels in Patients with Ulcerative Colitis.
2024
Journal of clinical medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Differential contributions of the gut microbiota and metabolome to pathomechanisms in ulcerative colitis: an in vitro analysis.
2024
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in amino acid concentrations and the gut microbiota composition are implicated in the mucosal healing of ulcerative colitis and can be used as noninvasive diagnostic biomarkers.
2024
Clinical proteomics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patient-donor similarity and donor-derived species contribute to the outcome of fecal microbiota transplantation for ulcerative colitis.
2025
Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mitigation of chemotherapy-induced gut dysbiosis and diarrhea by supplementation with heat-killed Bacteroides fragilis.
2025
BMC medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Environmental factors drive bacterial degradation of gastrointestinal mucus.
2025
NPJ biofilms and microbiomes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Detection of tissue colonizing bacteria and their association with clinicopathological and molecular features of inflammatory bowel disease.
2025
Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

1 papers
Microbially-catalyzed conjugation of GABA and tyramine to bile acids.
2023
bioRxiv : the preprint server for biology
Relevant preprint retained as supporting evidence, not central evidence.

Preclinical supporting evidence

35 papers
Monocolonization of germ-free mice with Bacteroides fragilis protects against dextran sulfate sodium-induced acute colitis.
2014
BioMed research international
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Anti-food and anti-microbial IgG subclass antibodies in inflammatory bowel disease.
2016
Scandinavian journal of gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Patient-Specific Bacteroides Genome Variants in Pouchitis.
2016
mBio
Disease-relevant preclinical or model-based paper useful as supporting evidence.
TLR2 and interleukin-10 are involved in Bacteroides fragilis-mediated prevention of DSS-induced colitis in gnotobiotic mice.
2017
PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Detection of enterotoxigenic Bacteroides fragilis in patients with ulcerative colitis.
2017
Gut pathogens
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation.
2020
Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Modulation of gut mucosal microbiota as a mechanism of probiotics-based adjunctive therapy for ulcerative colitis.
2020
Microbial biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Scutellaria baicalensis Georgi polysaccharide ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota.
2021
International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats.
2021
Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Icariin Inhibits Intestinal Inflammation of DSS-Induced Colitis Mice Through Modulating Intestinal Flora Abundance and Modulating p-p65/p65 Molecule.
2021
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The roles of different Bacteroides fragilis strains in protecting against DSS-induced ulcerative colitis and related functional genes.
2021
Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Berberine inhibits dendritic cells differentiation in DSS-induced colitis by promoting Bacteroides fragilis.
2021
International immunopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Hydrogen-rich water partially alleviate inflammation, oxidative stress and intestinal flora dysbiosis in DSS-induced chronic ulcerative colitis mice.
2022
Advances in medical sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Study of the gut microbiome in Egyptian patients with active ulcerative colitis.
2023
Revista de gastroenterologia de Mexico (English)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Nuciferine Regulates Immune Function and Gut Microbiota in DSS-Induced Ulcerative Colitis.
2022
Frontiers in veterinary science
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient.
2023
bioRxiv : the preprint server for biology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis attenuate clinical symptoms of experimental colitis by regulating Treg/Th17 cell balance and intestinal barrier integrity.
2023
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Coptis chinensis and Berberine Ameliorate Chronic Ulcerative Colitis: An Integrated Microbiome-Metabolomics Study.
2023
The American journal of Chinese medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
peu-MIR2916-p3-enriched garlic exosomes ameliorate murine colitis by reshaping gut microbiota, especially by boosting the anti-colitic Bacteroides thetaiotaomicron.
2024
Pharmacological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A novel conjugative transposon carrying an autonomously amplified plasmid.
2024
mBio
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bergenin Alleviates Ulcerative Colitis By Decreasing Gut Commensal Bacteroides vulgatus-Mediated Elevated Branched-Chain Amino Acids.
2024
Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota.
2024
Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The roles of different Bacteroides uniformis strains in alleviating DSS-induced ulcerative colitis and related functional genes.
2024
Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Atorvastatin improved ulcerative colitis in association with gut microbiota-derived tryptophan metabolism.
2024
Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Coptisine alleviates colitis through modulating gut microbiota and inhibiting TXNIP/NLRP3 inflammasome.
2024
Journal of ethnopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides fragilis in saliva: investigating links with ulcerative colitis.
2024
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Vinegar-processed Schisandra Chinensis enhanced therapeutic effects on colitis-induced depression through tryptophan metabolism.
2024
Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis.
2024
Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Polyphenols-rich Portulaca oleracea L. (purslane) alleviates ulcerative colitis through restiring the intestinal barrier, gut microbiota and metabolites.
2025
Food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides fragilis capsular polysaccharide A ameliorates ulcerative colitis in rat by recovering intestinal barrier integrity and restoring gut microbiota.
2024
Frontiers in pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Luteolin Alleviates Ulcerative Colitis in Mice by Modulating Gut Microbiota and Plasma Metabolism.
2025
Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
β-1,3-glucans from Euglena Gracilis protects against ulcerative colitis via modulating the gut barrier, T-cell immunity and gut microbiota.
2025
International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota-related glutathione metabolism is key mechanism for sulforaphane ameliorating ulcerative colitis.
2025
The Journal of nutritional biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Beneficial Effects of Apple Polyphenol Extract and Time-Restricted Feeding on Ulcerative Colitis and Accompanying Depression-like Behaviors Are Correlated with Gut-Brain Axis Modulation.
2025
Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Akkermansia muciniphila-derived extracellular vesicles alleviate colitis-related cognitive impairment via tryptophan metabolic reprogramming of the gut‒brain axis.
2026
Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

9 papers
Intestinal bacteria and ulcerative colitis.
2003
Current issues in intestinal microbiology
Relevant review or meta-analysis for the signal-disease area.
Update on the etiology, pathogenesis and diagnosis of ulcerative colitis.
2004
Nature clinical practice. Gastroenterology & hepatology
Relevant review or meta-analysis for the signal-disease area.
Impact of Klebsiella pneumoniae in lower gastrointestinal tract diseases.
2018
Journal of digestive diseases
Relevant review or meta-analysis for the signal-disease area.
Carcinogenic microbiota and its role in colorectal cancer development.
2022
Seminars in cancer biology
Relevant review or meta-analysis for the signal-disease area.
Systematic review of donor and recipient predictive biomarkers of response to faecal microbiota transplantation in patients with ulcerative colitis.
2022
EBioMedicine
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota, inflammatory bowel disease and colorectal cancer.
2022
World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Pathobionts in Inflammatory Bowel Disease: Origins, Underlying Mechanisms, and Implications for Clinical Care.
2024
Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota-based discovery of Houttuyniae Herba as a novel prebiotic of Bacteroides thetaiotaomicron with anti-colitis activity.
2024
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota as a mediator of cancer development and management: From colitis to colitis-associated dysplasia and carcinoma.
2025
Biochimica et biophysica acta. Reviews on cancer
Relevant review or meta-analysis for the signal-disease area.