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Bacteroides fragilis

obesity

Bacteroides fragilis looks like a credible signal in obesity, though some caution is still warranted.

Bacteroides fragilis shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.

bacteroides_fragilis
Credibility score
100
Human translation
3/5
Reproducibility
5/5
Novelty
1/5
Actionability
5/5
Credibility 100Human translation 3/5Reproducibility 5/5Novelty 1/5Actionability 5/5
Why this scores the way it does
  • strong central evidence base
  • meaningful supporting human literature
  • dense review literature
Main caveats
  • retrieval noise or disease-specificity issues may remain

Internal review flags

2 flags
review_heavy

Review literature is very dense relative to primary central evidence.

high_exclusion_volume

Many retrieved papers were excluded. Retrieval may be broad or disease specificity may be noisy.

Primary central evidence

28 papers
Pharmacokinetics and pharmacodynamics of linezolid in obese patients with cellulitis.
2005
The Annals of pharmacotherapy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The microbiota of the gut in preschool children with normal and excessive body weight.
2012
Obesity (Silver Spring, Md.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The intestinal microbiota composition and weight development in children: the KOALA Birth Cohort Study.
2015
International journal of obesity (2005)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The gut microbial community in metabolic syndrome patients is modified by diet.
2016
The Journal of nutritional biochemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Correlation between body mass index and faecal microbiota from children.
2016
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta-omics-based approach.
2017
Hepatology (Baltimore, Md.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The effects of the Lactobacillus casei strain on obesity in children: a pilot study.
2017
Beneficial microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Does birth mode modify associations of maternal pre-pregnancy BMI and gestational weight gain with the infant gut microbiome?
2020
International journal of obesity (2005)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Citrus polymethoxyflavones attenuate metabolic syndrome by regulating gut microbiome and amino acid metabolism.
2020
Science advances
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The effects of 6 mo of supplementation with probiotics and synbiotics on gut microbiota in the adults with prediabetes: A double blind randomized clinical trial.
2020
Nutrition (Burbank, Los Angeles County, Calif.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of a Low-Fat Vegan Diet on Gut Microbiota in Overweight Individuals and Relationships with Body Weight, Body Composition, and Insulin Sensitivity. A Randomized Clinical Trial.
2020
Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in gut microbial flora after Roux-en-Y gastric bypass and sleeve gastrectomy and their effects on post-operative weight loss.
2021
Updates in surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota alterations reveal potential gut-brain axis changes in polycystic ovary syndrome.
2021
Journal of endocrinological investigation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Modulation of the Gut Microbiota and Serum Biomarkers After Laparoscopic Sleeve Gastrectomy: a 1-Year Follow-Up Study.
2021
Obesity surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A metabolomics pipeline for the mechanistic interrogation of the gut microbiome.
2021
Nature
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Consortium of Indigenous Fecal Bacteria in the Treatment of Metabolic Syndrome.
2022
Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enterotypes in asthenospermia patients with obesity.
2022
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer.
2023
Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Liver Bacterial Colonization in Patients with Obesity and Gut Dysbiosis.
2024
Obesity surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of differences in intestinal flora associated with different BMI status in colorectal cancer patients.
2024
Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbial genomes with paired isolates from China illustrate probiotic and cardiometabolic effects.
2024
Cell genomics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The association between gut microbiota and resting metabolic rate in overweight/obese women: a case-control study.
2024
Journal of diabetes and metabolic disorders
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss Bifidobacterium breve BBr60 Intervention: A Randomized Controlled Trial.
2024
International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study.
2024
Genome medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota-derived 4-hydroxyphenylacetic acid from resveratrol supplementation prevents obesity through SIRT1 signaling activation.
2025
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Application of integrated in vitro fecal cultivation and 16S rRNA gene sequencing for optimizing beneficial gut microbiota combinations.
2025
Journal of microbiological methods
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrated gut microbiota and metabolomic profiling reveals key associations between amino acid levels and gut microbial composition in patients with obesity.
2025
Frontiers in nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial Biotransformation of Chicory by Bacteroides fragilis: In Vitro Implications for Obesity-Related Psoriasis.
2025
International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

3 papers
Interplay between weight loss and gut microbiota composition in overweight adolescents.
2009
Obesity (Silver Spring, Md.)
Human primary paper with plausible association relevance to the disease context.
16S rRNA of Mucosal Colon Microbiome and CCL2 Circulating Levels Are Potential Biomarkers in Colorectal Cancer.
2021
International journal of molecular sciences
Human primary paper with plausible association relevance to the disease context.
Gut colonization by Bacteroides fragilis at juvenile age alters microbiota composition and accelerates type 1 diabetes progression in non-obese diabetic mice.
2025
bioRxiv : the preprint server for biology
Relevant preprint retained as supporting evidence, not central evidence.

Preclinical supporting evidence

25 papers
Modulation of the intestinal microbiota is associated with lower plasma cholesterol and weight gain in hamsters fed chardonnay grape seed flour.
2015
Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.
2015
Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.
2016
Cell
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention.
2017
Nature medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.
2018
Nature medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism.
2020
The British journal of nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis.
2021
Cell metabolism
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of Konjaku Flour on the Gut Microbiota of Obese Patients.
2022
Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The human gut microbiota contributes to type-2 diabetes non-resolution 5-years after Roux-en-Y gastric bypass.
2022
Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides fragilis Supplementation Deteriorated Metabolic Dysfunction, Inflammation, and Aorta Atherosclerosis by Inducing Gut Microbiota Dysbiosis in Animal Model.
2022
Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The interplay between PCOS pathology and diet on gut microbiota in a mouse model.
2022
Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota accelerates obesity in peri-/post-menopausal women via Bacteroides fragilis and acetic acid.
2022
International journal of obesity (2005)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism.
2022
Nature metabolism
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Characterization of the microbiome and volatile compounds in anal gland secretions from domestic cats (Felis catus) using metagenomics and metabolomics.
2023
Research square
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut colonization with an obesity-associated enteropathogenic microbe modulates the premetastatic niches to promote breast cancer lung and liver metastasis.
2023
Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Genome-scale metabolic modeling of the human gut bacterium Bacteroides fragilis strain 638R.
2023
PLoS computational biology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Characterization of the microbiome and volatile compounds in anal gland secretions from domestic cats (Felis catus) using metagenomics and metabolomics.
2023
Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Anti-obesity activity of human gut microbiota Bacteroides stercoris KGMB02265.
2023
Archives of microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Semaglutide alleviates gut microbiota dysbiosis induced by a high-fat diet.
2024
European journal of pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice.
2024
Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice but not in chow-fed mice.
2024
Proceedings of the National Academy of Sciences of the United States of America
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic-Comorbidities Related Signatures in Craniopharyngioma.
2024
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The role of gut microbiota in Tirzepatide-mediated alleviation of high-fat diet-induced obesity.
2025
European journal of pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human Gut Commensal Bacteroides fragilis Suppresses Mucin Production and Alters Microbiota Composition Resulting in Accelerated Type 1 Diabetes in Mice.
2026
Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Electroacupuncture Exerts Anti-Obesity Effects by Affecting the Gut Microbiota and Upregulating Acetic Acid and 5-HT Levels in Obese Rats.
2025
Diabetes, metabolic syndrome and obesity : targets and therapy
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

24 papers
Host-bacterial mutualism in the human intestine.
2005
Science (New York, N.Y.)
Relevant review or meta-analysis for the signal-disease area.
Influence of gut microbiota on the development and progression of nonalcoholic steatohepatitis.
2018
European journal of nutrition
Relevant review or meta-analysis for the signal-disease area.
Diet and microbiota linked in health and disease.
2018
Food & function
Relevant review or meta-analysis for the signal-disease area.
Childhood Obesity and Firmicutes/Bacteroidetes Ratio in the Gut Microbiota: A Systematic Review.
2018
Childhood obesity (Print)
Relevant review or meta-analysis for the signal-disease area.
Microbial enterotypes in personalized nutrition and obesity management.
2018
The American journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Next generation probiotics in disease amelioration.
2019
Journal of food and drug analysis
Relevant review or meta-analysis for the signal-disease area.
Gut Dysbiosis and Intestinal Barrier Dysfunction: Potential Explanation for Early-Onset Colorectal Cancer.
2021
Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Human microbiome and metabolic health: An overview of systematic reviews.
2022
Obesity reviews : an official journal of the International Association for the Study of Obesity
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota and physical exercise in obesity and diabetes - A systematic review.
2022
Nutrition, metabolism, and cardiovascular diseases : NMCD
Relevant review or meta-analysis for the signal-disease area.
Next generation probiotics: an overview of the most promising candidates.
2022
Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota: Therapeutic Targets of Ginseng Against Multiple Disorders and Ginsenoside Transformation.
2022
Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
The Role of Next-Generation Probiotics in Obesity and Obesity-Associated Disorders: Current Knowledge and Future Perspectives.
2023
International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer.
2023
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Relevant review or meta-analysis for the signal-disease area.
Can prebiotics help tackle the childhood obesity epidemic?
2023
Frontiers in endocrinology
Relevant review or meta-analysis for the signal-disease area.
The Effects of the Mediterranean Diet on Health and Gut Microbiota.
2023
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Effects of gut microbiome and obesity on the development, progression and prevention of cancer (Review).
2024
International journal of oncology
Relevant review or meta-analysis for the signal-disease area.
Meta-analysis reveals obesity associated gut microbial alteration patterns and reproducible contributors of functional shift.
2024
Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Impact of vaginal seeding on the gut microbiome of infants born via cesarean section: A systematic review.
2024
The Journal of infection
Relevant review or meta-analysis for the signal-disease area.
Effects of GLP-1 Analogues and Agonists on the Gut Microbiota: A Systematic Review.
2025
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Emerging New Treatments for Colon Cancer.
2025
Current medicinal chemistry
Relevant review or meta-analysis for the signal-disease area.
Microbiota-derived metabolites in tumorigenesis: mechanistic insights and therapeutic implications.
2025
Frontiers in pharmacology
Relevant review or meta-analysis for the signal-disease area.
The gut microbiota-bile acid axis: a crucial regulator of immune function and metabolic health.
2025
World journal of microbiology & biotechnology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome-Mediated Genetic and Epigenetic Alterations in Colorectal Cancer: Population-Specific Insights.
2025
Biomedicines
Relevant review or meta-analysis for the signal-disease area.
From obesity to cancer: Gut microbiome mechanisms, biomarkers, and U.S. public health strategies.
2025
Oncoscience
Relevant review or meta-analysis for the signal-disease area.