preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
fulltophigh inflation risk
Bacteroides fragilis
crohn's disease
Bacteroides fragilis has meaningful literature visibility in crohn's disease, but the current evidence mix suggests a substantial risk of overclaiming.
Bacteroides fragilis shows a strong literature footprint in crohn's disease, with substantial central evidence and broader supporting literature.
bacteroides_fragilis
Credibility score
88
Human translation
2/5
Reproducibility
5/5
Novelty
1/5
Actionability
5/5
Credibility 88Human translation 2/5Reproducibility 5/5Novelty 1/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- dense review literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
- retrieval noise or disease-specificity issues may remain
Internal review flags
1 flagsPrimary central evidence
25 papersGenotyping of Bacteroides fragilis isolates from stool specimens by arbitrarily-primed-PCR.
2000Diagnostic microbiology and infectious disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enterotoxigenic Bacteroides fragilis.
2008Current infectious disease reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal detection of enterotoxigenic Bacteroides fragilis.
2015European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations in the mucosa-associated bacterial composition in Crohn's disease: a pilot study.
2016International journal of colorectal disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Quantitative microbiome profiling links gut community variation to microbial load.
2017Nature
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of Gut Microbiome and Diet Modification in Patients with Crohn's Disease.
2014SOJ microbiology & infectious diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gastrointestinal Pathobionts in Pediatric Crohn's Disease Patients.
2018International journal of microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.
2019Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis.
2019Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin.
2019Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enterotoxigenic Bacteroides fragilis: A Possible Etiological Candidate for Bacterially-Induced Colorectal Precancerous and Cancerous Lesions.
2019Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Gut Microbial Profile of Preclinical Crohn's Disease Is Similar to That of Healthy Controls.
2020Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Quantitative changes in selected bacteria in the stool during the treatment of Crohn's disease.
2020Advances in medical sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Inter-kingdom relationships in Crohn's disease explored using a multi-omics approach.
2021Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enterotoxigenic Bacteroidesfragilis Promotes Intestinal Inflammation and Malignancy by Inhibiting Exosome-Packaged miR-149-3p.
2021Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity.
2022Nature microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Location-specific signatures of Crohn's disease at a multi-omics scale.
2022Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of IBD-Associated Dysbiosis on Bacterial Quorum Sensing Mediated by Acyl-Homoserine Lactone in Human Gut Microbiota.
2022International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease.
2024Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrated Analysis of Microbiome and Metabolome Reveals Disease-Specific Profiles in Inflammatory Bowel Diseases and Intestinal Behçet's Disease.
2024International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease.
2024Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacteroides fragilis Toxin Suppresses METTL3-Mediated m6A Modification in Macrophage to Promote Inflammatory Bowel Disease.
2025Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Human colitis-associated colorectal carcinoma progression is accompanied by dysbiosis with enriched pathobionts.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Estrogen-related receptor alpha mitigates radiation-induced bowel injury through gut enrichment of Bacteroides vulgatus.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Decoding IBD progression: a dynamic biomarker atlas for personalized disease stratification.
2025Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersGene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease.
2016Science (New York, N.Y.)
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
30 papersEnterotoxigenic bacteroides fragilis: a potential instigator of colitis.
2007Inflammatory bowel diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diet rapidly and reproducibly alters the human gut microbiome.
2014Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.
2017Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Detection of enterotoxigenic Bacteroides fragilis in patients with ulcerative colitis.
2017Gut pathogens
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Non-toxigenic Bacteroides fragilis (NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A.
2019Mucosal immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation.
2020Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Zerumbone Restores Gut Microbiota Composition in ETBF Colonized AOM/DSS Mice.
2020Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dietary Salt Administration Decreases Enterotoxigenic Bacteroides fragilis (ETBF)-Promoted Tumorigenesis via Inhibition of Colonic Inflammation.
2020International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats.
2021Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Higher Prevalence of Bacteroides fragilis in Crohn's Disease Exacerbations and Strain-Dependent Increase of Epithelial Resistance.
2021Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Discovery of bioactive microbial gene products in inflammatory bowel disease.
2022Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Development and Clinical Application of a Multilocus Sequence Typing Scheme for Bacteroides fragilis Based on Whole-Genome Sequencing Data.
2023Microbiology spectrum
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Influence of inflammatory bowel disease on intestinal microflora.
1978Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis attenuate clinical symptoms of experimental colitis by regulating Treg/Th17 cell balance and intestinal barrier integrity.
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Genome-scale metabolic modeling of the human gut bacterium Bacteroides fragilis strain 638R.
2023PLoS computational biology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Porphyromonas gingivalis aggravates colitis via a gut microbiota-linoleic acid metabolism-Th17/Treg cell balance axis.
2024Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota.
2024Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides uniformis degrades β-glucan to promote Lactobacillus johnsonii improving indole-3-lactic acid levels in alleviating colitis.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides vesicles promote functional alterations in the gut microbiota composition.
2024Microbiology spectrum
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Vinegar-processed Schisandra Chinensis enhanced therapeutic effects on colitis-induced depression through tryptophan metabolism.
2024Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A highly conserved SusCD transporter determines the import and species-specific antagonism of Bacteroides ubiquitin homologues.
2024Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis.
2024Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides uniformis ameliorates pro-inflammatory diet-exacerbated colitis by targeting endoplasmic reticulum stress-mediated ferroptosis.
2025Journal of advanced research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The inflammatory bowel disease and gut microbiome are restored by employing metformin-loaded alginate-shelled microcapsules.
2025Journal of controlled release : official journal of the Controlled Release Society
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Identification of a secreted protease from Bacteroides fragilis that induces intestinal pain and inflammation by cleavage of PAR2.
2025bioRxiv : the preprint server for biology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Thalidomide mitigates Crohn's disease colitis by modulating gut microbiota, metabolites, and regulatory T cell immunity.
2025Journal of pharmaceutical analysis
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The gut microbiome and metabolomic alterations underlying colitis-induced encephalopathy in mice: mechanistic insight.
2025Behavioral and brain functions : BBF
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Multiomics Analysis of Bacteroides cellulosilyticus Anticolitis via Gut Microbiota Metabolite-Mediated PI3K-Akt Signaling Pathway.
2025Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides Fragilis-Derived Outer Membrane Vesicles Deliver MiR-5119 and Alleviate Colitis by Targeting PD-L1 to Inhibit GSDMD-Mediated Neutrophil Extracellular Trap Formation.
2025Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation.
2025Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
18 papers[Bacterial translocation in Crohn disease].
1992Gastroenterologie clinique et biologique
Relevant review or meta-analysis for the signal-disease area.
Enterotoxigenic Bacteroides fragilis: a rogue among symbiotes.
2009Clinical microbiology reviews
Relevant review or meta-analysis for the signal-disease area.
The Role of HSP70 Heat Shock Proteins in the Pathogenesis and Treatment of Inflammatory Bowel Diseases.
2015Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Relevant review or meta-analysis for the signal-disease area.
Role of antibiotics for treatment of inflammatory bowel disease.
2016World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Isolation, Detection, and Characterization of Enterotoxigenic Bacteroides fragilis in Clinical Samples.
2016The open microbiology journal
Relevant review or meta-analysis for the signal-disease area.
Smoking and the intestinal microbiome.
2018Archives of microbiology
Relevant review or meta-analysis for the signal-disease area.
Adherent-invasive Escherichia coli (AIEC): Cause or consequence of inflammation, dysbiosis, and rupture of cellular joints in patients with IBD?
2020Journal of cellular physiology
Relevant review or meta-analysis for the signal-disease area.
The multiple sclerosis gut microbiota: A systematic review.
2020Multiple sclerosis and related disorders
Relevant review or meta-analysis for the signal-disease area.
T-cell immunoglobulin and ITIM domain, as a potential immune checkpoint target for immunotherapy of colorectal cancer.
2021IUBMB life
Relevant review or meta-analysis for the signal-disease area.
Carcinogenic microbiota and its role in colorectal cancer development.
2022Seminars in cancer biology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Is a Potential Biomarker in Inflammatory Bowel Disease.
2021Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.
Intestinal phages interact with bacteria and are involved in human diseases.
2022Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota, inflammatory bowel disease and colorectal cancer.
2022World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Crosstalk between microbial biofilms in the gastrointestinal tract and chronic mucosa diseases.
2023Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Pathobionts in Inflammatory Bowel Disease: Origins, Underlying Mechanisms, and Implications for Clinical Care.
2024Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Effects of gut microbiome and obesity on the development, progression and prevention of cancer (Review).
2024International journal of oncology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota as a mediator of cancer development and management: From colitis to colitis-associated dysplasia and carcinoma.
2025Biochimica et biophysica acta. Reviews on cancer
Relevant review or meta-analysis for the signal-disease area.
Anaerobic gut bacteria and their potential role in the initiation, exacerbation, and development of human colorectal cancer: a narrative review.
2025Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.