Human intestinal microbiota: characterization of a simplified and stable gnotobiotic rat model.
2011Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
fulltoplow inflation risk
Anaerostipes hadrus
obesity
Anaerostipes hadrus looks like a credible signal in obesity, though some caution is still warranted.
Anaerostipes hadrus shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.
anaerostipes_hadrus
Credibility score
73
Human translation
4/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 73Human translation 4/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Primary central evidence
26 papersDiscovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients.
2020Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Probiotic-enriched milk and dairy products increase gut microbiota diversity: a comparative study.
2020Nutrition research (New York, N.Y.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients.
2021Clinical nutrition (Edinburgh, Scotland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota of Chinese Obese Children and Adolescents With and Without Insulin Resistance.
2021Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A predictive regression model of the obesity-related inflammatory status based on gut microbiota composition.
2021International journal of obesity (2005)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy.
2021Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Average gut flora in healthy Japanese subjects stratified by age and body mass index.
2022Bioscience of microbiota, food and health
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Effect of Short-Term Consumption of Lactic Acid Bacteria on the Gut Microbiota in Obese People.
2022Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Intestinal Microbiota and Short-Chain Fatty Acids in Association with Advanced Metrics of Glycemia and Adiposity Among Young Adults with Type 1 Diabetes and Overweight or Obesity.
2022Current developments in nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
d-Arabitol Ameliorates Obesity and Metabolic Disorders via the Gut Microbiota-SCFAs-WAT Browning Axis.
2023Journal of agricultural and food chemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Associations of disordered eating with the intestinal microbiota and short-chain fatty acids among young adults with type 1 diabetes.
2023Nutrition, metabolism, and cardiovascular diseases : NMCD
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Compliance with Nutritional Recommendations and Gut Microbiota Profile in Galician Overweight/Obese and Normal-Weight Individuals.
2023Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Long-Term Changes to the Microbiome, Blood Lipid Profiles and IL-6 in Female and Male Swedish Patients in Response to Bariatric Roux-en-Y Gastric Bypass.
2024Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome signatures associated with type 2 diabetes in obesity in Mongolia.
2024Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations in the gut microbiota community are associated with childhood obesity and precocious puberty.
2024BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of dark sweet cherry (Prunus avium) supplementation on the fecal microbiota, metabolic endotoxemia, and intestinal permeability in obese subjects: a single-blind randomized trial.
2024Food & function
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of oral metformin on gut microbiota characteristics and metabolite fractions in normal-weight type 2 diabetic mellitus patients.
2024Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association analysis of gut microbiota with LDL-C metabolism and microbial pathogenicity in colorectal cancer patients.
2024Lipids in health and disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecal microbiota composition and impulsivity in a cohort of older adults with metabolic syndrome.
2024Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-omics analyses of the gut microbiota and metabolites in children with metabolic dysfunction-associated steatotic liver disease.
2025mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of gut microbiota with overweight/obesity combined with gestational diabetes mellitus.
2025Journal of medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacteroides- and Prevotella-enriched gut microbial clusters associate with metabolic risks.
2025Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Distinct gut microbiota profiles and network properties in older Korean individuals with subjective cognitive decline, mild cognitive impairment, and Alzheimer's disease.
2025Alzheimer's research & therapy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in microbiota associated with the use of intragastric balloons.
2025Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The association between gut microbiome and hypertension varies according to enterotypes: a Korean study.
2023Frontiers in microbiomes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersA 4-Week Diet Low or High in Advanced Glycation Endproducts Has Limited Impact on Gut Microbial Composition in Abdominally Obese Individuals: The deAGEing Trial.
2022International journal of molecular sciences
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
10 papersThe ability of human intestinal anaerobes to metabolize different oligosaccharides: Novel means for microbiota modulation?
2018Anaerobe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Association of gut microbiome with fasting triglycerides, fasting insulin and obesity status in Mexican children.
2021Pediatric obesity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Eight-week exercise training in humans with obesity: Marked improvements in insulin sensitivity and modest changes in gut microbiome.
2021Obesity (Silver Spring, Md.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Alteration of Gut Microbiota Relates to Metabolic Disorders in Primary Aldosteronism Patients.
2021Frontiers in endocrinology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Trait Energy and Fatigue May Be Connected to Gut Bacteria among Young Physically Active Adults: An Exploratory Study.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Conjugated linoleic acid ameliorates hepatic steatosis by modulating intestinal permeability and gut microbiota in ob/ob mice.
2022Food & nutrition research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Calorie restriction during gestation impacts maternal and offspring fecal microbiome in mice.
2024Frontiers in endocrinology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity.
2025Cell reports. Medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Intestinal Myo-Inositol Metabolism and Metabolic Effects of Myo-Inositol Utilizing Anaerostipes rhamnosivorans in Mice.
2025International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Impact of Mango Bagasse and Peel Confectionery Rich in Dietary Fiber on Gut Microbiota, Metabolite Profiles, and Genetic Regulation in High-Fat-Diet-Fed Wistar Rats.
2025Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
4 papersBifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut.
2016Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Gallstone Disease, Obesity and the Firmicutes/Bacteroidetes Ratio as a Possible Biomarker of Gut Dysbiosis.
2020Journal of personalized medicine
Relevant review or meta-analysis for the signal-disease area.
Health Effects and Mechanisms of Inulin Action in Human Metabolism.
2024Nutrients
Relevant review or meta-analysis for the signal-disease area.
Precocious puberty and gut microbiome: a systematic review and meta-analysis.
2025Pediatric research
Relevant review or meta-analysis for the signal-disease area.