review_heavy
Review literature is very dense relative to primary central evidence.
fulltopmoderate inflation risk
Alpha diversity
obesity
Alpha diversity looks like a credible signal in obesity, though some caution is still warranted.
Alpha diversity shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.
alpha_diversity
Credibility score
100
Human translation
3/5
Reproducibility
5/5
Novelty
1/5
Actionability
5/5
Credibility 100Human translation 3/5Reproducibility 5/5Novelty 1/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- meaningful supporting human literature
- dense review literature
Main caveats
- retrieval noise or disease-specificity issues may remain
Internal review flags
1 flagsPrimary central evidence
27 papersExercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia.
2020Medicine and science in sports and exercise
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Blood metabolome predicts gut microbiome α-diversity in humans.
2019Nature biotechnology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and metabolic health among overweight and obese individuals.
2020Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Oral Cyanobacteria and Hepatocellular Carcinoma.
2022Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Associations between maternal obesity and offspring gut microbiome in the first year of life.
2022Pediatric obesity
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Diet Quality and the Gut Microbiota in Women Living in Alabama.
2022American journal of preventive medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota is associated with metabolic health in children with obesity.
2022Clinical nutrition (Edinburgh, Scotland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: insights from the BE GONE trial.
2023EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Brief Report: Relationship Between Adiposity and Biomarkers of Aging and Frailty Among Adults Aging With HIV.
2024Journal of acquired immune deficiency syndromes (1999)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of a Cycling versus Running HIIT Program on Fat Mass Loss and Gut Microbiota Composition in Men with Overweight/Obesity.
2024Medicine and science in sports and exercise
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of differences in intestinal flora associated with different BMI status in colorectal cancer patients.
2024Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association between childhood obesity and gut microbiota: 16S rRNA gene sequencing-based cohort study.
2024World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Bifidobacterium breve 207-1 on regulating lifestyle behaviors and mental wellness in healthy adults based on the microbiome-gut-brain axis: a randomized, double-blind, placebo-controlled trial.
2024European journal of nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota transplantation alters gut phage communities in a clinical trial for obesity.
2024Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity.
2024International journal of obesity (2005)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Interactions between the gut microbiome, associated metabolites and the manifestation and progression of heart failure with preserved ejection fraction in ZSF1 rats.
2024Cardiovascular diabetology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in intestinal permeability and gut microbiota following diet-induced weight loss in patients with metabolic dysfunction-associated steatohepatitis and liver fibrosis.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association analysis of gut microbiota with LDL-C metabolism and microbial pathogenicity in colorectal cancer patients.
2024Lipids in health and disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dietary Antrodia cinnamomea Polysaccharide Intervention Modulates Clinical Symptoms by Regulating Ovarian Metabolites and Restructuring the Intestinal Microbiota in Rats with Letrozole-Induced PCOS.
2024Journal of agricultural and food chemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Sex-Dependent Gut Microbiota Features and Functional Signatures in Metabolic Disfunction-Associated Steatotic Liver Disease.
2024Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota: Association with Fiber Intake, Ultra-Processed Food Consumption, Sex, Body Mass Index, and Socioeconomic Status in Medical Students.
2024Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered Expression of Aromatase and Estrogen Receptors in Adipose Tissue From Men With Obesity or Type 2 Diabetes.
2025The Journal of clinical endocrinology and metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome shifts in adolescents after sleeve gastrectomy with increased oral-associated taxa and pro-inflammatory potential.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Distinct gut microbiota signatures in older people with sarcopenic obesity and sarcopenia without obesity.
2025Clinical nutrition (Edinburgh, Scotland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
TNF-α/NF-κB mediated upregulation of Dectin-1 in hyperglycemic obesity: implications for metabolic inflammation and diabetes.
2025Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Shifts After a Weight Loss Program in Adults with Obesity: The WLM3P Study.
2025Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Relationships among host genetics, gut microbiota, and asthma in US Hispanic/Latino adults.
2025Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
5 papersEvidence in obese children: contribution of hyperlipidemia, obesity-inflammation, and insulin sensitivity.
2015PloS one
Human primary paper with plausible association relevance to the disease context.
Hepatic microbiome in healthy lean and obese humans.
2021JHEP reports : innovation in hepatology
Human primary paper with plausible association relevance to the disease context.
Effect of Concurrent Training on Body Composition and Gut Microbiota in Postmenopausal Women with Overweight or Obesity.
2022Medicine and science in sports and exercise
Human primary paper with plausible association relevance to the disease context.
Inflammatory markers and body mass index amoung hispanic children.
2024PloS one
Human primary paper with plausible association relevance to the disease context.
The effect of overweight/obesity and FTO gene polymorphism on liver function-related parameters in Chinese adolescents.
2024The National medical journal of India
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
20 papersProcessing and Analyzing Human Microbiome Data.
2017Methods in molecular biology (Clifton, N.J.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Obesity or Overweight, a Chronic Inflammatory Status in Male Reproductive System, Leads to Mice and Human Subfertility.
2017Frontiers in physiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Association and interaction of the FTO rs1421085 with overweight/obesity in a sample of Pakistani individuals.
2020Eating and weight disorders : EWD
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility.
2020EBioMedicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice.
2020Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver.
2021Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Probiotic Strain H. alvei HA4597® Improves Weight Loss in Overweight Subjects under Moderate Hypocaloric Diet: A Proof-of-Concept, Multicenter Randomized, Double-Blind Placebo-Controlled Study.
2021Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Obesity Modulates the Gut Microbiome in Triple-Negative Breast Cancer.
2021Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparative analysis of gut microbiota in healthy and diarrheic yaks.
2022Microbial cell factories
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The interplay between PCOS pathology and diet on gut microbiota in a mouse model.
2022Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Walking and taking vitamin C alleviates oxidative stress and inflammation in overweight students, even in the short-term.
2022Frontiers in public health
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of PPARG and PPARGC1A gene polymorphisms on obesity markers.
2022Frontiers in public health
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis.
2024Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats.
2024Biological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with type 2 diabetes mellitus: A single-blind cross-over trial.
2024The Journal of physiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Long-Term Exposure to Polystyrene Microspheres and High-Fat Diet-Induced Obesity in Mice: Evaluating a Role for Microbiota Dysbiosis.
2024Environmental health perspectives
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of Resistance Training on Muscular Adaptations and Inflammatory Markers in Overweight and Obese Men.
2025Medicine and science in sports and exercise
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gastric microbiota-specific signatures in adults with obesity and Helicobacter pylori-negative gastritis.
2025European journal of clinical investigation
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Association between oral microbiome diversity and kidney stones: a cross-sectional study.
2025Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Three Kampo medicines-bofutsushosan, boiogito, and daisaikoto-have different effects on host fat accumulation and the intestinal microbiota in a high-fat-diet-induced mouse model of obesity.
2025Journal of natural medicines
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
35 papersMechanisms of TNF-alpha-induced insulin resistance.
1999Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
Relevant review or meta-analysis for the signal-disease area.
Leptin signaling, adiposity, and energy balance.
2002Annals of the New York Academy of Sciences
Relevant review or meta-analysis for the signal-disease area.
Genetics and pathophysiology of human obesity.
2003Annual review of medicine
Relevant review or meta-analysis for the signal-disease area.
The management of hypertension in the overweight and obese patient: is weight reduction sufficient?
2004Drugs
Relevant review or meta-analysis for the signal-disease area.
Short stature, obesity, and growth hormone deficiency in pseudohypoparathyroidism type 1a.
2006Pediatric endocrinology reviews : PER
Relevant review or meta-analysis for the signal-disease area.
Body composition differences in normal weight, obese-overweight and anorexic adolescents: role of adipocytokines.
2010Medicine and sport science
Relevant review or meta-analysis for the signal-disease area.
Effect of overweight/obesity on response to periodontal treatment: systematic review and a meta-analysis.
2015Journal of clinical periodontology
Relevant review or meta-analysis for the signal-disease area.
Looking for a Signal in the Noise: Revisiting Obesity and the Microbiome.
2016mBio
Relevant review or meta-analysis for the signal-disease area.
Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes.
2017The Journal of nutrition
Relevant review or meta-analysis for the signal-disease area.
Mechanistic Basis for Obesity-related Increases in Ozone-induced Airway Hyperresponsiveness in Mice.
2017Annals of the American Thoracic Society
Relevant review or meta-analysis for the signal-disease area.
Systematic review: human gut dysbiosis induced by non-antibiotic prescription medications.
2018Alimentary pharmacology & therapeutics
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota phenotypes of obesity.
2019NPJ biofilms and microbiomes
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome: Profound Implications for Diet and Disease.
2019Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut-brain Axis and migraine headache: a comprehensive review.
2020The journal of headache and pain
Relevant review or meta-analysis for the signal-disease area.
Zinc-alpha2-glycoprotein, dysglycaemia and insulin resistance: a systematic review and meta-analysis.
2020Reviews in endocrine & metabolic disorders
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota in Patients with Polycystic Ovary Syndrome: a Systematic Review.
2022Reproductive sciences (Thousand Oaks, Calif.)
Relevant review or meta-analysis for the signal-disease area.
Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity.
2021Mediators of inflammation
Relevant review or meta-analysis for the signal-disease area.
Maternal exposures and the infant gut microbiome: a systematic review with meta-analysis.
2021Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis.
2021Nutrients
Relevant review or meta-analysis for the signal-disease area.
The association of weight loss with changes in the gut microbiota diversity, composition, and intestinal permeability: a systematic review and meta-analysis.
2022Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Gut microbiome and health: mechanistic insights.
2022Gut
Relevant review or meta-analysis for the signal-disease area.
The relationship between the gut microbiota, benign prostatic hyperplasia, and erectile dysfunction.
2023International journal of impotence research
Relevant review or meta-analysis for the signal-disease area.
SNPs, adipokynes and adiposity in children with asthma.
2023The Journal of asthma : official journal of the Association for the Care of Asthma
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Characteristics of People with Obesity by Meta-Analysis of Existing Datasets.
2022Nutrients
Relevant review or meta-analysis for the signal-disease area.
The human gut microbiota and glucose metabolism: a scoping review of key bacteria and the potential role of SCFAs.
2022The American journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Maternal weight status and the composition of the human milk microbiome: A scoping review.
2022PloS one
Relevant review or meta-analysis for the signal-disease area.
The role of FTO variant rs1421085 in the relationship with obesity: a systematic review and meta-analysis.
2022Eating and weight disorders : EWD
Relevant review or meta-analysis for the signal-disease area.
Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis.
2023Frontiers in oncology
Relevant review or meta-analysis for the signal-disease area.
Meta-analysis reveals gut microbiome and functional pathway alterations in response to resistant starch.
2023Food & function
Relevant review or meta-analysis for the signal-disease area.
Effect of Per and Poly-Fluoroalkyl Substances on Pregnancy and Child Development.
2025Current pediatric reviews
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Regulation by Acupuncture and Moxibustion: A Systematic Review and Meta-Analysis.
2024The American journal of Chinese medicine
Relevant review or meta-analysis for the signal-disease area.
Exploring PPAR Gamma and PPAR Alpha's Regulation Role in Metabolism via Epigenetics Mechanism.
2024Biomolecules
Relevant review or meta-analysis for the signal-disease area.
Microbiome-centered therapies for the management of metabolic dysfunction-associated steatotic liver disease.
2025Clinical and molecular hepatology
Relevant review or meta-analysis for the signal-disease area.
Cannabis and cannabinoid-microbiome interactions in varied clinical contexts: A comprehensive systematic review.
2025Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Relevant review or meta-analysis for the signal-disease area.
Hypertension in obese patients.
1993Postgraduate medicine
Relevant review or meta-analysis for the signal-disease area.