review_heavy
Review literature is very dense relative to primary central evidence.
fulltopmoderate inflation risk
Alpha diversity
inflammatory bowel disease
Alpha diversity looks like a credible signal in inflammatory bowel disease, though some caution is still warranted.
Alpha diversity shows a strong literature footprint in inflammatory bowel disease, with substantial central evidence and broader supporting literature.
alpha_diversity
Credibility score
100
Human translation
3/5
Reproducibility
5/5
Novelty
1/5
Actionability
5/5
Credibility 100Human translation 3/5Reproducibility 5/5Novelty 1/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- meaningful supporting human literature
- dense review literature
Main caveats
- retrieval noise or disease-specificity issues may remain
Internal review flags
1 flagsPrimary central evidence
40 papersSubcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis.
2014Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease.
2018Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Cytomegalovirus, inflammatory bowel disease, and anti-TNFα.
2017International journal of colorectal disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbial dysbiosis in Chinese patients with inflammatory bowel disease.
2018World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of fungal dysbiosis in Japanese patients with inflammatory bowel disease.
2019Journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Host Genetic and Gut Microbial Signatures in Familial Inflammatory Bowel Disease.
2020Clinical and translational gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Inflammatory Bowel Disease Outcomes Following Fecal Microbiota Transplantation for Recurrent C. difficile Infection.
2021Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Attributes of intestinal microbiota composition and their correlation with clinical primary non-response to anti-TNF-α agents in inflammatory bowel disease patients.
2022Bosnian journal of basic medical sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The gut fungal and bacterial microbiota in pediatric patients with inflammatory bowel disease introduced to treatment with anti-tumor necrosis factor-α.
2022Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis in the Gut Microbiota in Patients with Inflammatory Bowel Disease during Remission.
2022Microbiology spectrum
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease.
2023Intestinal research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Differences in the Intestinal Flora of Patients with Inflammatory Bowel Disease in Southwest China.
2022Indian journal of microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intercontinental Gut Microbiome Variances in IBD.
2022International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Potential of Gut Microbe-Derived Extracellular Vesicles to Differentiate Inflammatory Bowel Disease Patients from Healthy Controls.
2023Gut and liver
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome and mycobiome in inflammatory bowel disease patients with Clostridioides difficile infection.
2023Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of bowel cleansing on the composition of the gut microbiota in inflammatory bowel disease patients and healthy controls.
2023Therapeutic advances in gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
CRP in Outpatients with Inflammatory Bowel Disease Is Linked to the Blood Microbiota.
2023International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota signatures in inflammatory bowel disease.
2024United European gastroenterology journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis and Associated Stool Features Improve Prediction of Response to Biological Therapy in Inflammatory Bowel Disease.
2024Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Evaluation of Bacterial and Fungal Biomarkers for Differentiation and Prognosis of Patients with Inflammatory Bowel Disease.
2023Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Oncostatin M Induces a Pro-inflammatory Phenotype in Intestinal Subepithelial Myofibroblasts.
2024Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Surgery for Crohn's Disease Is Associated With a Dysbiotic Microbiome and Metabolome: Results From Two Prospective Cohorts.
2024Cellular and molecular gastroenterology and hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease.
2024Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota.
2024mBio
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiota in Mild Inflammatory Bowel Disease (IBD) Can Be Modulated by Beta-Glucans and Mannanoligosaccharides: A Randomized, Double-Blinded Study in Dogs.
2024Veterinary sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dietary Determinants of Metabolic and Gut Microbial Health in Patients with Inflammatory Bowel Disease.
2024Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Acupuncture and Moxibustion for Inflammatory Bowel Disease: Regulatory Mechanisms Revealed by Microbiome and Metabolomic Analysis.
2024The American journal of Chinese medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Evaluation of intestinal biopsy tissue preservation methods to facilitate large-scale mucosal microbiota research.
2025EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome shifts in adolescents after sleeve gastrectomy with increased oral-associated taxa and pro-inflammatory potential.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota transplantation for vancomycin-resistant Clostridium innocuum infection in inflammatory bowel disease: A pilot study evaluating safety and clinical and microbiota outcome.
2025Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Human colitis-associated colorectal carcinoma progression is accompanied by dysbiosis with enriched pathobionts.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of the salivary microbiome of adults with inflammatory bowel disease.
2025Journal of oral microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
In vitro fermentation of yeast cell walls (mannan-oligosaccharide) and purified β-glucans modulates the colonic microbiota of dogs with inflammatory bowel disease and demonstrates protective effects on barrier integrity and anti-inflammatory properties.
2025PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal gut microbiota and amino acids as noninvasive diagnostic biomarkers of Pediatric inflammatory bowel disease.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Whole Food Diet Induces Remission in Children and Young Adults With Mild to Moderate Crohn's Disease and Is More Tolerable Than Exclusive Enteral Nutrition: A Randomized Controlled Trial.
2025Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mycobiota dynamics in inflammatory bowel disease: Fungal biomarkers and Clostridioides difficile co-infection.
2025Microbial pathogenesis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metagenomic Sequencing Reveals Distinct Gut Microbiome Profiles in Therapy-Naïve de Novo Pediatric Inflammatory Bowel Disease.
2026Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Are More Strongly Associated With Impairments in Health-Related Quality of Life Than Disease Activity in Inflammatory Bowel Disease.
2025The American journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Decoding IBD progression: a dynamic biomarker atlas for personalized disease stratification.
2025Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Tissue and stool microbiome in pediatric inflammatory bowel disease patients: diversity differs in patients with relapsing and non-relapsing Crohn's disease.
2025Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
2 papersThe microbiome of translocated bacterial populations in patients with and without inflammatory bowel disease.
2018Internal medicine journal
Human primary paper with plausible association relevance to the disease context.
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after Fecal Microbiota Transplant in Inflammatory Bowel Disease.
2023medRxiv : the preprint server for health sciences
Relevant preprint retained as supporting evidence, not central evidence.
Preclinical supporting evidence
22 papersFarnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease.
2011Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Spondyloarthropathy in inflammatory bowel disease patients on TNF inhibitors.
2015Internal medicine journal
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice.
2020Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Parthenolide ameliorates colon inflammation through regulating Treg/Th17 balance in a gut microbiota-dependent manner.
2020Theranostics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Angiogenin maintains gut microbe homeostasis by balancing α-Proteobacteria and Lachnospiraceae.
2021Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota.
2021Autophagy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Infliximab-induced optic neuritis.
2020BMJ case reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
B. adolescentis ameliorates chronic colitis by regulating Treg/Th2 response and gut microbiota remodeling.
2021Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Protective Role of Spermidine in Colitis and Colon Carcinogenesis.
2022Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Taxifolin Alleviates DSS-Induced Ulcerative Colitis by Acting on Gut Microbiome to Produce Butyric Acid.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Mucosa-Colonizing Microbiota Correlate With Host Autophagy Signaling in Patients With Inflammatory Bowel Disease.
2022Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Molecular and Functional Characterization of Human Intestinal Organoids and Monolayers for Modeling Epithelial Barrier.
2023Inflammatory bowel diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparison of vaginal microbiota between women with inflammatory bowel disease and healthy controls.
2023PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis.
2024Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Microbiota Profile Changes in Patients with Inflammatory Bowel Disease and Non-Alcoholic Fatty Liver Disease: A Metagenomic Study.
2024International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
AhR Activation Transcriptionally Induces Anti-Microbial Peptide Alpha-Defensin 1 Leading to Reversal of Gut Microbiota Dysbiosis and Colitis.
2025Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbiota-derived IPA alleviates intestinal mucosal inflammation through upregulating Th1/Th17 cell apoptosis in inflammatory bowel disease.
2025Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Polysaccharides from Cistanche deserticola mitigate inflammatory bowel disease via modulating intestinal microbiota and SRC/EGFR/PI3K/AKT signaling pathways.
2025International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Enterococcus faecalis hijacks FABP2 to activate quorum-sensing signals and aggravate Crohn's disease by inducing gut dysbiosis.
2025Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Xanthohumol Alleviates Inflammatory Bowel Disease-Associated Osteoporosis via Regulating Gut Microbial Metabolites.
2025Phytotherapy research : PTR
Disease-relevant preclinical or model-based paper useful as supporting evidence.
PD-L1 deficiency exacerbates colitis severity by remodeling gut microbiota in inflammatory bowel disease.
2025Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease.
2025Journal of periodontology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
37 papers[Inflammatory bowel disease and lung].
2006Tuberkuloz ve toraks
Relevant review or meta-analysis for the signal-disease area.
Viral hepatitis and inflammatory bowel disease.
2010Inflammatory bowel diseases
Relevant review or meta-analysis for the signal-disease area.
Psoriasis.
2013The journal of the Royal College of Physicians of Edinburgh
Relevant review or meta-analysis for the signal-disease area.
Therapeutic drug monitoring in patients with inflammatory bowel disease.
2014World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Nocardia infections among immunomodulated inflammatory bowel disease patients: A review.
2015World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Anti-TNF agents in patients with inflammatory bowel disease and malignant melanoma--challenges in management.
2015International journal of colorectal disease
Relevant review or meta-analysis for the signal-disease area.
Pharmacological- and non-pharmacological therapeutic approaches in inflammatory bowel disease in adults.
2016World journal of gastrointestinal pharmacology and therapeutics
Relevant review or meta-analysis for the signal-disease area.
Inflammatory Bowel Disease: Joint Management in Gastroenterology and Dermatology.
2017Actas dermo-sifiliograficas
Relevant review or meta-analysis for the signal-disease area.
Management of Inflammatory Bowel Disease in the Elderly Patient: Challenges and Opportunities.
2017Inflammatory bowel diseases
Relevant review or meta-analysis for the signal-disease area.
Current understanding of microbiota- and dietary-therapies for treating inflammatory bowel disease.
2018Journal of microbiology (Seoul, Korea)
Relevant review or meta-analysis for the signal-disease area.
Allergic and Immunologic Perspectives of Inflammatory Bowel Disease.
2019Clinical reviews in allergy & immunology
Relevant review or meta-analysis for the signal-disease area.
Update on the Use of Thiopurines and Methotrexate in Inflammatory Bowel Disease.
2018Current gastroenterology reports
Relevant review or meta-analysis for the signal-disease area.
Thiopurine Therapy in Patients With Inflammatory Bowel Disease: A Focus on Metabolism and Pharmacogenetics.
2019Digestive diseases and sciences
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome: Profound Implications for Diet and Disease.
2019Nutrients
Relevant review or meta-analysis for the signal-disease area.
Inflammatory bowel disease and targeted oral anti-TNFα therapy.
2020Advances in protein chemistry and structural biology
Relevant review or meta-analysis for the signal-disease area.
Pharmacogenetics of inflammatory bowel disease.
2021Pharmacogenomics
Relevant review or meta-analysis for the signal-disease area.
The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases.
2021Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Profile in Pediatric Patients With Inflammatory Bowel Disease: A Systematic Review.
2021Frontiers in pediatrics
Relevant review or meta-analysis for the signal-disease area.
Shared microbiological and immunological patterns in periodontitis and IBD: A scoping review.
2022Oral diseases
Relevant review or meta-analysis for the signal-disease area.
Repeated Fecal Microbial Transplantations and Antibiotic Pre-Treatment Are Linked to Improved Clinical Response and Remission in Inflammatory Bowel Disease: A Systematic Review and Pooled Proportion Meta-Analysis.
2021Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.
Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis.
2021International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Inflammatory Bowel Disease-related Behaviours [IBD-Bx] Questionnaire: Development, Validation and Prospective Associations with Fatigue.
2022Journal of Crohn's & colitis
Relevant review or meta-analysis for the signal-disease area.
Systematic review: the association between the gut microbiota and medical therapies in inflammatory bowel disease.
2022Alimentary pharmacology & therapeutics
Relevant review or meta-analysis for the signal-disease area.
The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management.
2022Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Searching for a Consensus Among Inflammatory Bowel Disease Studies: A Systematic Meta-Analysis.
2023Inflammatory bowel diseases
Relevant review or meta-analysis for the signal-disease area.
Seronegative spondyloarthropathy-associated inflammatory bowel disease.
2023World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Assessing the Relationship between the Gut Microbiota and Inflammatory Bowel Disease Therapeutics: A Systematic Review.
2023Pathogens (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Non-culture-based studies of the appendiceal microbiota: a systematic review.
2023Future microbiology
Relevant review or meta-analysis for the signal-disease area.
Precision medicine in inflammatory bowel disease: Individualizing the use of biologics and small molecule therapies.
2023World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives.
2023World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiome, metabolome, host immunity associated with inflammatory bowel disease and intervention of fecal microbiota transplantation.
2023Journal of autoimmunity
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota and metabolites as predictors of biologics response in inflammatory bowel disease: A comprehensive systematic review.
2024Microbiological research
Relevant review or meta-analysis for the signal-disease area.
Inflammatory Bowel Diseases and the Efficacy of Probiotics as Functional Foods.
2024Frontiers in bioscience (Elite edition)
Relevant review or meta-analysis for the signal-disease area.
Ulcerative colitis: molecular insights and intervention therapy.
2024Molecular biomedicine
Relevant review or meta-analysis for the signal-disease area.
Association of Gut Microbiome and Dipeptidyl Peptidase 4 in Immune-Mediated Inflammatory Bowel Disease: A Rapid Literature Review.
2024International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Gut Mycobiome in Inflammatory Bowel Disease: A Systematic Review of Case-Control Studies.
2025Inflammatory bowel diseases
Relevant review or meta-analysis for the signal-disease area.
The Gut Microbiome at the Onset of Inflammatory Bowel Disease: A Systematic Review and Unified Bioinformatic Synthesis.
2026Gastroenterology
Relevant review or meta-analysis for the signal-disease area.