review_heavy
Review literature is very dense relative to primary central evidence.
fulltopmoderate inflation risk
Alpha diversity
colorectal cancer
Alpha diversity looks like a credible signal in colorectal cancer, though some caution is still warranted.
Alpha diversity shows a strong literature footprint in colorectal cancer, with substantial central evidence and broader supporting literature.
alpha_diversity
Credibility score
100
Human translation
4/5
Reproducibility
5/5
Novelty
1/5
Actionability
5/5
Credibility 100Human translation 4/5Reproducibility 5/5Novelty 1/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- meaningful supporting human literature
- dense review literature
Main caveats
- retrieval noise or disease-specificity issues may remain
Internal review flags
1 flagsPrimary central evidence
47 papersMicroRNA MIR21 and T Cells in Colorectal Cancer.
2016Cancer immunology research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alpha-fetoprotein-producing rectal cancer successfully responded to preoperative chemoradiotherapy: case report.
2018Surgical case reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity.
2019Nature microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
SENP1 participates in Irinotecan resistance in human colon cancer cells.
2021Journal of cellular biochemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Role of Intestinal Microbiota in Metastatic Colorectal Cancer Patients Treated With Capecitabine.
2022Clinical colorectal cancer
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Human α-defensin 6 (HD6) suppresses CRC proliferation and metastasis through abolished EGF/EGFR signaling pathway.
2022International journal of medical sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Colorectal Cancer-Associated Microbiome Patterns and Signatures.
2021Frontiers in genetics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of fecal microbiome in biopsy positive prostate cancer patients.
2022BJUI compass
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways.
2022Cells
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota composition in colorectal cancer patients is genetically regulated.
2022Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrated metagenomic and metabolomic analysis reveals distinct gut-microbiome-derived phenotypes in early-onset colorectal cancer.
2023Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota composition in chemotherapy and targeted therapy of patients with metastatic colorectal cancer.
2022Frontiers in oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
2022Clinical nutrition (Edinburgh, Scotland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of the gut microbiome using extracellular vesicles in the urine of patients with colorectal cancer.
2023The Korean journal of internal medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Prospective and Cross-sectional Associations of the Rectal Tissue Microbiome with Colorectal Adenoma Recurrence.
2023Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Prediction model of poorly differentiated colorectal cancer (CRC) based on gut bacteria.
2022BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Oral Microbiota as Novel Biomarkers for Colorectal Cancer Screening.
2022Cancers
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Influence of neo-adjuvant radiotherapy on the intestinal microbiota of rectal cancer patients.
2023Journal of cancer research and clinical oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Relationship between Chemotherapy-Induced Diarrhea and Intestinal Microbiome Composition.
2023Digestion
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome associated with low anterior resection syndrome after rectal cancer surgery.
2023Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression.
2023Cell reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Correlation of gut microbiota with leukopenia after chemotherapy in patients with colorectal cancer.
2023BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: insights from the BE GONE trial.
2023EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Systematic Evaluation of Clinical, Nutritional, and Fecal Microbial Factors for Their Association With Colorectal Polyps.
2024Clinical and translational gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comprehensive characterization of PKHD1 mutation in human colon cancer.
2024Cancer medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Distinct intratumoral microbiome of young-onset and average-onset colorectal cancer.
2024EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of differences in intestinal flora associated with different BMI status in colorectal cancer patients.
2024Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrated analysis of gut microbiota and metabolomic profiling in colorectal cancer metastasis.
2024Environmental toxicology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Autoprobiotics in the Treatment of Patients with Colorectal Cancer in the Early Postoperative Period.
2024Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiome and colorectal cancer: discovery of bacterial changes with metagenomics application in Turkısh population.
2024Genes & genomics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers.
2024Cancer cell
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota drives colon cancer risk associated with diet: a comparative analysis of meat-based and pesco-vegetarian diets.
2024Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-Cohort Analysis Reveals Altered Archaea in Colorectal Cancer Fecal Samples Across Populations.
2025Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of Gut Microbiome in Patients with Colorectal Advanced Adenoma by Metagenomic Analyses.
2024The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome-Based Colon Cancer Patient Stratification and Survival Analysis.
2024Cancer medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Inactivation of glutathione S-transferase alpha 4 blocks Enterococcus faecalis-induced bystander effect by promoting macrophage ferroptosis.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The gut microbiome is associated with disease-free survival in stage I-III colorectal cancer patients.
2025International journal of cancer
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of a high-fiber, high-fruit and high-vegetable, low-fat dietary intervention on the rectal tissue microbiome.
2025Journal of the National Cancer Institute
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Genetic variants in glycosylation pathways are associated with colorectal cancer risk.
2025Carcinogenesis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered microbiota of rectal mucosa in rectal cancer patients.
2025World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Hypoxia facilitates stemness of colon cancer cells via histone lactylation.
2025Biochimica et biophysica acta. Molecular basis of disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exploring the gut microbiota associated with peripheral nerve invasion in colorectal cancer patients and constructing predictive models.
2025BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Distinct microbiota composition and dendritic cell activation in the appendix microenvironment of ulcerative colitis patients.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Associations of the Colon Tissue Microbiome and Circulating Bile Acids With Colorectal Adenoma Among Average-Risk Women.
2025Cancer medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Age-diet interactions significantly influence intratumoral gene expression, gut microbiome signature and tumor microenvironment in colorectal cancer.
2025Neoplasia (New York, N.Y.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Primary tumor microbiomes predict distant metastasis of colorectal cancer.
2025NPJ precision oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of Helicobacter pylori infection on gut and intratumoral microbiome and its association with immunotherapy response in gastrointestinal cancer.
2026BMC medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
2 papersMapping the colorectal tumor microbiota.
2021Gut microbes
Human primary paper with plausible association relevance to the disease context.
Primary tumor microbiomes predict distant metastasis of colorectal cancer.
2025bioRxiv : the preprint server for biology
Relevant preprint retained as supporting evidence, not central evidence.
Preclinical supporting evidence
24 papersA purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice.
2020Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Paroxetine Administration Affects Microbiota and Bile Acid Levels in Mice.
2020Frontiers in psychiatry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Changes in Microbial Community Composition Related to Sex and Colon Cancer by Nrf2 Knockout.
2021Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Protective Role of Spermidine in Colitis and Colon Carcinogenesis.
2022Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ganluyin ameliorates DSS-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-κB pathway.
2022Journal of ethnopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Metagenomic Analyses of Multiple Gut Datasets Revealed the Association of Phage Signatures in Colorectal Cancer.
2022Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ginsenoside Rb1 Suppresses AOM/DSS-induced Colon Carcinogenesis.
2023Anti-cancer agents in medicinal chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches.
2023Computational and structural biotechnology journal
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8+ T cells.
2023Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Nanobody-Based EGFR-Targeting Immunotoxins for Colorectal Cancer Treatment.
2023Biomolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bifidobacterium adolescentis orchestrates CD143+ cancer-associated fibroblasts to suppress colorectal tumorigenesis by Wnt signaling-regulated GAS1.
2023Cancer communications (London, England)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
TCM syndrome differentiation in colorectal cancer patients assisted by differences in gut microbiota: An exploratory study.
2023Heliyon
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect of Extracelluar Vesicles Derived from Akkermansia muciniphila on Intestinal Barrier in Colitis Mice.
2023Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Identification of unique rectal cancer-specific subtypes.
2024British journal of cancer
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Synthesis and biological evaluation of echinomycin analogues as potential colon cancer agent.
2024Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactococcus lactis HkyuLL 10 suppresses colorectal tumourigenesis and restores gut microbiota through its generated alpha-mannosidase.
2024Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Commensal microbiota-derived metabolite agmatine triggers inflammation to promote colorectal tumorigenesis.
2024Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Isocitrate dehydrogenases 2-mediated dysfunctional metabolic reprogramming promotes intestinal cancer progression via regulating HIF-1A signaling pathway.
2024International immunopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Alteration of ascending colon mucosal microbiota in patients after cholecystectomy.
2024World journal of gastrointestinal surgery
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Inhibition of the NF-κB/HIF-1α signaling pathway in colorectal cancer by tyrosol: a gut microbiota-derived metabolite.
2024Journal for immunotherapy of cancer
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance.
2025Molecular oncology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Oral administration of Folium Artemisiae Argyi-derived exosome-like nanovesicles can improve ulcerative colitis by regulating intestinal microorganisms.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Extracellular vesicle-induced lipid dysregulation drives liver premetastatic niche formation in colorectal cancer.
2025Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Eubacterium limosum modulates tumor microenvironments and produces antitumor metabolites active against colorectal cancer.
2025The ISME journal
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
25 papersAdjuvant therapy of colon cancer.
1999CA: a cancer journal for clinicians
Relevant review or meta-analysis for the signal-disease area.
Tocopherols and the treatment of colon cancer.
2004Annals of the New York Academy of Sciences
Relevant review or meta-analysis for the signal-disease area.
Alpha-fetoprotein-producing early rectal carcinoma: a rare case report and review.
2015World journal of surgical oncology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota and Colorectal Cancer.
2015Gastrointestinal tumors
Relevant review or meta-analysis for the signal-disease area.
Inflammatory networks underlying colorectal cancer.
2016Nature immunology
Relevant review or meta-analysis for the signal-disease area.
ALOX15 as a suppressor of inflammation and cancer: Lost in the link.
2017Prostaglandins & other lipid mediators
Relevant review or meta-analysis for the signal-disease area.
Expression and role of nuclear receptor coregulators in colorectal cancer.
2017World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Crosstalk between gut microbiota and antidiabetic drug action.
2019World journal of diabetes
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome: Profound Implications for Diet and Disease.
2019Nutrients
Relevant review or meta-analysis for the signal-disease area.
Comparing alternating pressure mattresses and high-specification foam mattresses to prevent pressure ulcers in high-risk patients: the PRESSURE 2 RCT.
2019Health technology assessment (Winchester, England)
Relevant review or meta-analysis for the signal-disease area.
Role of TGF-Beta and Smad7 in Gut Inflammation, Fibrosis and Cancer.
2020Biomolecules
Relevant review or meta-analysis for the signal-disease area.
Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects.
2021Pharmacological research
Relevant review or meta-analysis for the signal-disease area.
Are the FTO Gene Polymorphisms Associated with Colorectal Cancer? A Meta-analysis.
2021Journal of gastrointestinal cancer
Relevant review or meta-analysis for the signal-disease area.
Ulcerative Colitis: Rapid Evidence Review.
2022American family physician
Relevant review or meta-analysis for the signal-disease area.
Extracellular vesicles-mediated interaction within intestinal microenvironment in inflammatory bowel disease.
2022Journal of advanced research
Relevant review or meta-analysis for the signal-disease area.
The Tissue-Associated Microbiota in Colorectal Cancer: A Systematic Review.
2022Cancers
Relevant review or meta-analysis for the signal-disease area.
The Clinical Significance and Role of CXCL1 Chemokine in Gastrointestinal Cancers.
2023Cells
Relevant review or meta-analysis for the signal-disease area.
Influence of the bile acid/microbiota axis in ileal surgery: a systematic review.
2024Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Relevant review or meta-analysis for the signal-disease area.
Probiotic Functions in Fermented Foods: Anti-Viral, Immunomodulatory, and Anti-Cancer Benefits.
2024Foods (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Inflammation: Is It a Healer, Confounder, or a Promoter of Cardiometabolic Risks?
2024Biomolecules
Relevant review or meta-analysis for the signal-disease area.
Aspirin for colorectal cancer chemoprevention: where are we?
2025Current opinion in oncology
Relevant review or meta-analysis for the signal-disease area.
Cross-cohort analysis identifies shared gut microbial signatures and validates microbial risk scores for colorectal cancer.
2025Journal of translational medicine
Relevant review or meta-analysis for the signal-disease area.
Meta-analysis of gut microbiome reveals patterns of dysbiosis in colorectal cancer patients.
2025Journal of medical microbiology
Relevant review or meta-analysis for the signal-disease area.
Association of the gut microbiome to colorectal anastomotic leakage: systematic review.
2025BJS open
Relevant review or meta-analysis for the signal-disease area.
Tocopherols and the etiology of colon cancer.
1997Journal of the National Cancer Institute
Relevant review or meta-analysis for the signal-disease area.