sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Alistipes
obesity
Alistipes looks like a credible signal in obesity, though some caution is still warranted.
Alistipes shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.
alistipes
Credibility score
77
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 77Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
25 papersObese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition.
2019Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities.
2019Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Baseline Gut Microbiota Directs Dieting-Induced Weight Loss Trajectories.
2021Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota of Chinese Obese Children and Adolescents With and Without Insulin Resistance.
2021Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Taxonomic Characterization and Short-Chain Fatty Acids Production of the Obese Microbiota.
2021Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association between metabolic status and gut microbiome in obese populations.
2021Microbial genomics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota link dietary fiber intake and short-chain fatty acid metabolism with eating behavior.
2021Translational psychiatry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrative Analysis of Gut Microbiota and Fecal Metabolites in Rats after Prednisone Treatment.
2021Microbiology spectrum
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in the gut microbiota of morbidly obese patients after laparoscopic sleeve gastrectomy.
2022Future microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Predictive Role of Gut Microbiota in Weight Loss Achievement after Bariatric Surgery.
2022Journal of the American College of Surgeons
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Low-Carbohydrate Diet and Exercise Training on Gut Microbiota.
2022Frontiers in nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota is associated with dietary intake and metabolic markers in healthy individuals.
2022Food & nutrition research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and acylcarnitine metabolites connect the beneficial association between equol and adiposity in adults: a prospective cohort study.
2022The American journal of clinical nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrating the serum proteomic and fecal metaproteomic to analyze the impacts of overweight/obesity on IBD: a pilot investigation.
2023Clinical proteomics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of intestinal microbiota and its metabolite markers with excess weight in Chinese children and adolescents.
2023Pediatric obesity
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Plant-based diets and the gut microbiome: findings from the Baltimore Longitudinal Study of Aging.
2024The American journal of clinical nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity.
2024Environment international
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Breastfeeding Shapes the Gut Microbiota and Its Structure Is Associated with Weight Gain Trajectories in Mexican Infants.
2025Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Distinct gut microbiota signatures in older people with sarcopenic obesity and sarcopenia without obesity.
2025Clinical nutrition (Edinburgh, Scotland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Links between gut microbiota with specific serum metabolite groups in pregnant women with overweight or obesity.
2025Nutrition, metabolism, and cardiovascular diseases : NMCD
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dietary switch and intermittent fasting ameliorate the disrupted postprandial short-chain fatty acid response in diet-induced obese mice.
2025EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alistipes putredinis Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease in Rats via Gut Microbiota Remodeling and Inflammatory Suppression.
2025Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The ecology of the microbiota in children with obesity is associated with the intake of carbohydrates and insulin resistance.
2025Clinical nutrition (Edinburgh, Scotland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Theaflavins in black tea ameliorate high-fat diet-induced obesity and inflammation via gut microbiota, AMPK-mediated metabolism, and NF-κB pathway.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Body mass index distinctly modulates the associations between Alistipes and CRP/IL-6 in metabolic and lupus inflammatory features.
2025PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
16 papersInhibitory Effect of Garcinol on Obesity-Exacerbated, Colitis-Mediated Colon Carcinogenesis.
2021Molecular nutrition & food research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Seabuckthorn polysaccharide ameliorates high-fat diet-induced obesity by gut microbiota-SCFAs-liver axis.
2022Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Distinct Diet-Microbiota-Metabolism Interactions in Overweight and Obese Pregnant Women: a Metagenomics Approach.
2022Microbiology spectrum
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota-directed intervention with high-amylose maize ameliorates metabolic dysfunction in diet-induced obese mice.
2022Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Influence of Adiposity on the Gut Microbiota Composition of Arab Women: A Case-Control Study.
2022Biology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Aloe Vera-Fermented Beverage Ameliorates Obesity and Gut Dysbiosis in High-Fat-Diet Mice.
2022Foods (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Association of gut microbiota and glucose metabolism in children with disparate degrees of adiposity.
2023Pediatric obesity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice.
2023EBioMedicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gualou-Xiebai-Banxia-Tang regulates liver-gut axis to ameliorate Metabolic Syndrome in HFD-fed mice.
2024Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic-Comorbidities Related Signatures in Craniopharyngioma.
2024Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Arabinoxylan Alleviates Obesity by Regulating Gut Microbiota and Bile Acid Metabolism.
2024Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus plantarum L11 and Lactobacillus reuteri LR: Ameliorate Obesity via AMPK Pathway.
2024Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Curcumin mitigates obesity-driven dysbiosis and liver steatosis while promoting browning and thermogenesis in white adipose tissue of high-fat diet-fed mice.
2025The Journal of nutritional biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The role of gut microbiota in Tirzepatide-mediated alleviation of high-fat diet-induced obesity.
2025European journal of pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Curcumin ameliorates hepatic steatosis and insulin resistance through the JNK2/FOXO1/Bcl6 axis and regulate the intestinal flora structure.
2025Journal of physiology and biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactiplantibacillus plantarum Lp20 Alleviates High Fat Diet-Induced Obesity in Mice via Its Bile Salt Hydrolase Activity.
2025Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
10 papersGallstone Disease, Obesity and the Firmicutes/Bacteroidetes Ratio as a Possible Biomarker of Gut Dysbiosis.
2020Journal of personalized medicine
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota in patients with obesity and metabolic disorders - a systematic review.
2022Genes & nutrition
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Characteristics of People with Obesity by Meta-Analysis of Existing Datasets.
2022Nutrients
Relevant review or meta-analysis for the signal-disease area.
The Gut Microbiome and Female Health.
2022Biology
Relevant review or meta-analysis for the signal-disease area.
Relationship between changes in microbiota induced by resveratrol and its anti-diabetic effect on type 2 diabetes.
2022Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.
Contribution of the microbiome for better phenotyping of people living with obesity.
2023Reviews in endocrine & metabolic disorders
Relevant review or meta-analysis for the signal-disease area.
Exploring the role of gut microbiota dysbiosis in gout pathogenesis: a systematic review.
2023Frontiers in medicine
Relevant review or meta-analysis for the signal-disease area.
Meta-analysis reveals obesity associated gut microbial alteration patterns and reproducible contributors of functional shift.
2024Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Research summary, possible mechanisms and perspectives of gut microbiota changes causing precocious puberty.
2025Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.
Precocious puberty and gut microbiome: a systematic review and meta-analysis.
2025Pediatric research
Relevant review or meta-analysis for the signal-disease area.