preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
fulltophigh inflation risk
Alistipes
inflammatory bowel disease
Alistipes has meaningful literature visibility in inflammatory bowel disease, but the current evidence mix suggests a substantial risk of overclaiming.
Alistipes shows a strong literature footprint in inflammatory bowel disease, with substantial central evidence and broader supporting literature.
alistipes
Credibility score
54
Human translation
2/5
Reproducibility
4/5
Novelty
3/5
Actionability
4/5
Credibility 54Human translation 2/5Reproducibility 4/5Novelty 3/5Actionability 4/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
16 papersDynamics of metatranscription in the inflammatory bowel disease gut microbiome.
2018Nature microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Variability of core microbiota in newly diagnosed treatment-naïve paediatric inflammatory bowel disease patients.
2018PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Longitudinal Changes in Fecal Calprotectin Levels Among Pregnant Women With and Without Inflammatory Bowel Disease and Their Babies.
2021Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs.
2022Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrating the serum proteomic and fecal metaproteomic to analyze the impacts of overweight/obesity on IBD: a pilot investigation.
2023Clinical proteomics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrative multi-omics deciphers the spatial characteristics of host-gut microbiota interactions in Crohn's disease.
2023Cell reports. Medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Diagnosis of Crohn's disease and ulcerative colitis using the microbiome.
2023BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of microbial communities and the profile of sulfate-reducing bacteria in patients with ulcerative colitis and their association with bowel diseases: a pilot study.
2024Microbial cell (Graz, Austria)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial Disruptions in Inflammatory Bowel Disease: A Comparative Analysis.
2024International journal of general medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Specific Bacterial Co-abundance Groups Are Associated With Inflammatory Status in Patients With Ulcerative Colitis.
2025Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome related to metabolic diseases after moderate-to-vigorous intensity exercise.
2024Journal of exercise science and fitness
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiome Alterations Following Oral Serum-Derived Bovine Immunoglobulin Administration in the Management of Dysbiosis.
2024Cureus
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Panax notoginseng Saponins Alleviate Inflammatory Bowel Disease via Alteration of Gut Microbiota-Bile Acid Metabolism.
2025The American journal of Chinese medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal gut microbiota and amino acids as noninvasive diagnostic biomarkers of Pediatric inflammatory bowel disease.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered Gut Microbiota in Pediatric Quiescent Crohn's Disease Patients with Iron Deficiency Anemia.
2026Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacterial and fungal biomarkers in irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD): trans-kingdom interactions, Blastocystis carriage, and enterotype-succinotype stratification.
2026Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersHuman gut commensal Alistipes timonensis modulates the host lipidome and delivers anti-inflammatory outer membrane vesicles to suppress colitis in an Il10 -deficient mouse model.
2025bioRxiv : the preprint server for biology
Relevant preprint retained as supporting evidence, not central evidence.
Preclinical supporting evidence
28 papersDiet rapidly and reproducibly alters the human gut microbiome.
2014Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pglyrp-Regulated Gut Microflora Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii Enhance and Alistipes finegoldii Attenuates Colitis in Mice.
2016PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Prebiotics effects in vitro of polysaccharides from tea flowers on gut microbiota of healthy persons and patients with inflammatory bowel disease.
2020International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Glycine Attenuates Citrobacter rodentium-Induced Colitis by Regulating ATF6-Mediated Endoplasmic Reticulum Stress in Mice.
2021Molecular nutrition & food research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human Fecal Microbiota Transplantation Reduces the Susceptibility to Dextran Sulfate Sodium-Induced Germ-Free Mouse Colitis.
2022Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Prevention of Ulcerative Colitis in Mice by Sweet Tea (Lithocarpus litseifolius) via the Regulation of Gut Microbiota and Butyric-Acid-Mediated Anti-Inflammatory Signaling.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Linarin ameliorates dextran sulfate sodium-induced colitis in C57BL/6J mice via the improvement of intestinal barrier, suppression of inflammatory responses and modulation of gut microbiota.
2022Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A tetrapeptide from maize combined with probiotics exerted strong anti-inflammatory effects and modulated gut microbiota in DSS-induced colitis mice.
2022Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Heat-Killed Bifidobacterium bifidum B1628 May Alleviate Dextran Sulfate Sodium-Induced Colitis in Mice, and the Anti-Inflammatory Effect Is Associated with Gut Microbiota Modulation.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Functional analysis of metalloenzymes from human gut microbiota and their role in ulcerative colitis.
2023Journal of applied microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
TNF ΔARE Pigs: A Translational Crohn's Disease Model.
2023Journal of Crohn's & colitis
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Syringic Acid Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice by Modulating Gut Microbiota.
2023Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pretreatment with Bifidobacterium longum BAA2573 ameliorates dextran sulfate sodium (DSS)-induced colitis by modulating gut microbiota.
2023Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Salidroside alleviates dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota.
2023Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis.
2023Frontiers of medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Administration of intestinal mesenchymal stromal cells reduces colitis-associated cancer in C57BL/6J mice modulating the immune response and gut dysbiosis.
2023Pharmacological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Intravenous ferric carboxymaltose and ferric derisomaltose alter the intestinal microbiome in female iron-deficient anemic mice.
2023Bioscience reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Egg yolk phosphatidylcholine alleviates DSS-induced colitis in BALB/c mice.
2023Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiome-based thiamine metabolism contributes to the protective effect of one acidic polysaccharide from Selaginella uncinata (Desv.) Spring against inflammatory bowel disease.
2024Journal of pharmaceutical analysis
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Microbiota Profile Changes in Patients with Inflammatory Bowel Disease and Non-Alcoholic Fatty Liver Disease: A Metagenomic Study.
2024International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The gut microbiota-aromatic hydrocarbon receptor (AhR) axis mediates the anticolitic effect of polyphenol-rich extracts from Sanghuangporus.
2024iMeta
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lacticaseibacillus casei IB1 Alleviates DSS-Induced Inflammatory Bowel Disease by Regulating the Microbiota and Restoring the Intestinal Epithelial Barrier.
2024Microorganisms
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Vinegar-processed Schisandra Chinensis enhanced therapeutic effects on colitis-induced depression through tryptophan metabolism.
2024Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice.
2024Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Sodium Butyrate-Loaded Microspheres With Enhanced Bioavailability for Targeted Treatment of Intestinal Barrier Injury.
2025Advanced healthcare materials
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Hydroxytyrosol Ameliorates Colon Inflammation: Mechanistic Insights into Anti-Inflammatory Effects, Inhibition of the TLR4/NF-κB Signaling Pathway, Gut Microbiota Modulation, and Liver Protection.
2025Foods (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Therapeutic effect of Faecalibacterium longum CM04-06 on DSS-induced ulcerative colitis in mice.
2025Journal of applied microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human gut commensal Alistipes timonensis modulates the host lipidome and delivers anti-inflammatory outer membrane vesicles to suppress colitis in an Il10-deficient mouse model.
2025Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
1 papersGut microbiome remodeling induced by microplastic exposure in humans.
2026Gut microbes
Relevant review or meta-analysis for the signal-disease area.