preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedmidhigh inflation risk
Alistipes
autism
Alistipes has meaningful literature visibility in autism, but the current evidence mix suggests a substantial risk of overclaiming.
Alistipes shows a moderate evidence base in autism, with multiple central papers and additional supporting literature.
alistipes
Credibility score
24
Human translation
2/5
Reproducibility
2/5
Novelty
4/5
Actionability
2/5
Credibility 24Human translation 2/5Reproducibility 2/5Novelty 4/5Actionability 2/5
Why this scores the way it does
- moderate central evidence base
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
7 papersFecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified.
2013PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Diet Can Impact Microbiota Composition in Children With Autism Spectrum Disorder.
2018Frontiers in neuroscience
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The bacterial neurometabolic signature of the gut microbiota of young children with autism spectrum disorders.
2020Journal of medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Maternal Immune Activation Causes Social Behavior Deficits and Hypomyelination in Male Rat Offspring with an Autism-Like Microbiota Profile.
2021Brain sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder.
2022Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Associations Between Gut Microbes and Social Behavior in Healthy 2-Year-Old Children.
2022Psychosomatic medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metagenomic Characterization of Gut Microbiota in Children with Autism Spectrum Disorder: Microbial Signatures and Modulation by Anti-Inflammatory Diet and Probiotics.
2025Pharmaceuticals (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
10 papersAltered gut microbiota and activity in a murine model of autism spectrum disorders.
2014Brain, behavior, and immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
New evidences on the altered gut microbiota in autism spectrum disorders.
2017Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A pilot study to investigate the alteration of gut microbial profile in Dip2a knockout mice.
2022International microbiology : the official journal of the Spanish Society for Microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The live biotherapeutic Blautia stercoris MRx0006 attenuates social deficits, repetitive behaviour, and anxiety-like behaviour in a mouse model relevant to autism.
2022Brain, behavior, and immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus plantarum ST-III modulates abnormal behavior and gut microbiota in a mouse model of autism spectrum disorder.
2022Physiology & behavior
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fecal microbiota transplantation improves VPA-induced ASD mice by modulating the serotonergic and glutamatergic synapse signaling pathways.
2023Translational psychiatry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Maternal exposure of mice to glyphosate induces depression- and anxiety-like behavior in the offspring via alterations of the gut-brain axis.
2023The Science of the total environment
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The role of gut microbiota in modulating brain structure and psychiatric disorders: A Mendelian randomization study.
2025NeuroImage
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrated analysis of metabolome and microbiome in a mouse model of sodium valproate-induced autism.
2025Experimental biology and medicine (Maywood, N.J.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Multiomics analysis reveals the exacerbating effect of constipation on autism-related symptoms in children with autism spectrum disorder.
2026NPJ biofilms and microbiomes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
4 papersOverlapping Mechanisms of Action of Brain-Active Bacteria and Bacterial Metabolites in the Pathogenesis of Common Brain Diseases.
2022Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Profiles in Children and Adolescents with Psychiatric Disorders.
2022Microorganisms
Relevant review or meta-analysis for the signal-disease area.
The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders-An Evidence Mapping Based on Quantified Evidence.
2023Mediators of inflammation
Relevant review or meta-analysis for the signal-disease area.
Mechanistic Links Between Gut Dysbiosis, Insulin Resistance, and Autism Spectrum Disorder.
2025International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.